Polygenic Score (PGS) ID: PGS004942

Predicted Trait
Reported Trait Ischemic stroke
Mapped Trait(s) Ischemic stroke (HP_0002140)
Released in PGS Catalog: Aug. 29, 2024
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Score Details

Score Construction
PGS Name IS_MetaPRS
Development Method
Name MetaPRS
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 4,765,243
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000668
Citation (link to publication) China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 82.9%
East Asian: 12.7%
Not Reported: 4.4%
12,334,052 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005195
Europe PMC: 29212778
 547,261 individuals Not reported NR
GWAS Catalog: GCST010867
Europe PMC: 33020668
 168,228 individuals East Asian NR
GWAS Catalog: GCST90104540
Europe PMC: 36180795
 1,296,908 individuals European NR
GWAS Catalog: GCST90018644
Europe PMC: 34594039
 174,686 individuals East Asian NR
GWAS Catalog: GCST006624
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST90018752
Europe PMC: 34594039
 145,505 individuals East Asian NR
GWAS Catalog: GCST006630
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST90018732
Europe PMC: 34594039
 145,515 individuals East Asian NR
GWAS Catalog: GCST90239664
Europe PMC: 34887591
 1,320,016 individuals European NR
GWAS Catalog: GCST90018755
Europe PMC: 34594039
 111,667 individuals East Asian NR
GWAS Catalog: GCST90239676
Europe PMC: 34887591
 1,320,016 individuals European NR
GWAS Catalog: GCST90018754
Europe PMC: 34594039
 135,808 individuals East Asian NR
GWAS Catalog: GCST90239658
Europe PMC: 34887591
 1,320,016 individuals European NR
GWAS Catalog: GCST90018741
Europe PMC: 34594039
 72,866 individuals East Asian NR
GWAS Catalog: GCST90239652
Europe PMC: 34887591
 1,320,016 individuals European NR
GWAS Catalog: GCST90018736
Europe PMC: 34594039
 74,970 individuals East Asian NR
GWAS Catalog: GCST009379
Europe PMC: 30297969
 898,130 individuals European NR
GWAS Catalog: GCST90013693
Europe PMC: 32514122
 210,865 individuals East Asian NR
GWAS Catalog: GCST90002232
Europe PMC: 34059833
 200,622 individuals European NR
GWAS Catalog: GCST90244003
Europe PMC: 36333282
 288,127 individuals East Asian NR
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European NR
GWAS Catalog: GCST004373
Europe PMC: 28416822
 36,792 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021740 PSS011774|
East Asian Ancestry|
72,149 individuals
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Reported Trait: Incident ischemic stroke HR: 1.18 [1.16, 1.21] C-index: 0.733 [0.727, 0.738] — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011774 ICD10: I63 Median = 12.2 years 72,149 individuals,
40.2 % Male samples
 Mean = 51.7 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CKB —