Polygenic Score (PGS) ID: PGS004943

Predicted Trait
Reported Trait Intracerebral hemorrhage
Mapped Trait(s) intracerebral hemorrhage (EFO_0005669)
Released in PGS Catalog: Aug. 29, 2024
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Score Details

Score Construction
PGS Name ICH_MetaPRS
Development Method
Name MetaPRS
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 2,124,631
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000668
Citation (link to publication) China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 70.4%
East Asian: 20.7%
Not Reported: 8.8%
6,200,875 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005195
Europe PMC: 29212778
 547,261 individuals Not reported NR
GWAS Catalog: GCST010867
Europe PMC: 33020668
 168,228 individuals East Asian NR
GWAS Catalog: GCST90104540
Europe PMC: 36180795
 1,296,908 individuals European NR
GWAS Catalog: GCST90018644
Europe PMC: 34594039
 174,686 individuals East Asian NR
GWAS Catalog: GCST006624
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST90018752
Europe PMC: 34594039
 145,505 individuals East Asian NR
GWAS Catalog: GCST006630
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST90018732
Europe PMC: 34594039
 145,515 individuals East Asian NR
GWAS Catalog: GCST009379
Europe PMC: 30297969
 898,130 individuals European NR
GWAS Catalog: GCST90013693
Europe PMC: 32514122
 210,865 individuals East Asian NR
GWAS Catalog: GCST90002232
Europe PMC: 34059833
 200,622 individuals European NR
GWAS Catalog: GCST90244003
Europe PMC: 36333282
 288,127 individuals East Asian NR
GWAS Catalog: GCST90043994
Europe PMC: 34737426
 456,348 individuals European NR
GWAS Catalog: GCST90018650
Europe PMC: 34594039
 153,478 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021741 PSS011773|
East Asian Ancestry|
72,149 individuals
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Reported Trait: Incident intracerebral hemorrhage HR: 1.31 [1.24, 1.39] C-index: 0.748 [0.734, 0.761] — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011773 ICD10: I61 Median = 12.2 years 72,149 individuals,
40.2 % Male samples
 Mean = 51.7 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CKB —