PGS Publication: PGP000555

Publication Information (EuropePMC)
Title Assessing the performance of genetic risk score for stratifying risk of post-sepsis cardiovascular complications.
PubMed ID 36926049(Europe PMC)
doi 10.3389/fcvm.2023.1076745
Publication Date Feb. 28, 2023
Journal Front Cardiovasc Med
Author(s) McElligott B, Shi Z, Rifkin AS, Wei J, Zheng SL, Helfand BT, Woo JSH, Xu J.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004322
(GRS30_IS)
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Ischemic stroke stroke,
Ischemic stroke		 30
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004322/ScoringFiles/PGS004322.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020429 PGS004322
(GRS30_IS)
 PSS011358|
European Ancestry|
454,493 individuals
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Reported Trait: Incident ischaemic stroke HR: 1.26 [1.17, 1.35] — — age, gender, 10-yr ASCVD Risk by PCE, genetic background, and sepsis —
PPM020430 PGS004322
(GRS30_IS)
 PSS011358|
European Ancestry|
454,493 individuals
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Reported Trait: Any incident myocardial infarction, ischaemic stroke, or venous thromboembolism HR: 1.05 [1.01, 1.1] — — age, gender, 10-yr ASCVD Risk by PCE, genetic background, and sepsis —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011358 ICD-10 codes (I21, I22, I23, I24.1, and I25.2), ICD-9 codes (410, 411, 412, and 429.79) for MI, ICD-10 (I63, I64), ICD-9 (434 and 436) for IS — 454,493 individuals — European — UKB Mean age of full combined ancestry cohort = 56.9 years