PGS Publication: PGP000674

Publication Information (EuropePMC)
Title Genomic risk scores and oral contraceptive-associated ischemic stroke risk: a call for collaboration.
PubMed ID 38094903(Europe PMC)
doi 10.3389/fstro.2023.1143372
Publication Date Sept. 14, 2023
Journal Front Stroke
Author(s) Lin F, Tomppo L, Gaynor B, Ryan K, Cole JW, Mitchell BD, Putaala J, Kittner SJ.
Released in PGS Catalog: Sept. 19, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000039
(metaGRS_ischaemicstroke)
 PGP000027 |
Abraham G et al. Nat Commun (2019)
 Ischemic stroke stroke,
Ischemic stroke		 3,225,583
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000039/ScoringFiles/PGS000039.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021765 PGS000039
(metaGRS_ischaemicstroke)
 PSS011789|
European Ancestry|
332 individuals
 PGP000674 |
Lin F et al. Front Stroke (2023)
|Ext.		 Reported Trait: Ischemic stroke OR: 3.0 [0.3, 26.4] — — Age, smoking status —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011789 — —
[
  • 136 cases
  • , 196 controls
]
,
0.0 % Male samples
 — European — GEOS —