PGS Publication: PGP000335

Publication Information (EuropePMC)
Title Multiancestral polygenic risk score for pediatric asthma.
PubMed ID 35595084(Europe PMC)
doi 10.1016/j.jaci.2022.03.035
Publication Date May 18, 2022
Journal J Allergy Clin Immunol
Author(s) Namjou B, Lape M, Malolepsza E, DeVore SB, Weirauch MT, Dikilitas O, Jarvik GP, Kiryluk K, Kullo IJ, Liu C, Luo Y, Satterfield BA, Smoller JW, Walunas TL, Connolly J, Sleiman P, Mersha TB, Mentch FD, Hakonarson H, Prows CA, Biagini JM, Khurana Hershey GK, Martin LJ, Kottyan L, eMERGE Network.
Released in PGS Catalog: June 29, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002727
(PRS_PA)
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Asthma asthma 985,837
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002727/ScoringFiles/PGS002727.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014754 PGS002727
(PRS_PA)
 PSS009885|
East Asian Ancestry|
1,671 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.32 [0.99, 1.77] AUROC: 0.73 [0.66, 0.8] R²: 0.08 — —
PPM014755 PGS002727
(PRS_PA)
 PSS009887|
South Asian Ancestry|
8,736 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.32 [1.18, 1.48] AUROC: 0.65 [0.62, 0.68] R²: 0.03 — —
PPM014752 PGS002727
(PRS_PA)
 PSS009884|
African Ancestry|
7,818 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.43 [1.24, 1.65] AUROC: 0.66 [0.63, 0.69] R²: 0.03 — —
PPM014753 PGS002727
(PRS_PA)
 PSS009888|
Hispanic or Latin American Ancestry|
5,225 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.63 [1.36, 1.95] AUROC: 0.7 [0.67, 0.74] R²: 0.07 — —
PPM014751 PGS002727
(PRS_PA)
 PSS009886|
European Ancestry|
391,820 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.57 [1.55, 1.6] AUROC: 0.66 [0.65, 0.67] R²: 0.04 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009884 — —
[
  • 310 cases
  • , 7,508 controls
]
 — African unspecified — UKB —
PSS009885 — —
[
  • 49 cases
  • , 1,622 controls
]
 — East Asian — UKB —
PSS009886 — —
[
  • 15,586 cases
  • , 376,234 controls
]
 — European — UKB —
PSS009887 — —
[
  • 312 cases
  • , 8,424 controls
]
 — South Asian — UKB —
PSS009888 — —
[
  • 205 cases
  • , 5,020 controls
]
 — Hispanic or Latin American
(Admixed American)		 — UKB —