Polygenic Score (PGS) ID: PGS002727

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Released in PGS Catalog: June 29, 2022
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Score Details

Score Construction
PGS Name PRS_PA
Development Method
Name PRS-CS
Parameters MAF>1%
Variants
Original Genome Build GRCh37
Number of Variants 985,837
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000335
Citation (link to publication) Namjou B et al. J Allergy Clin Immunol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 89.6%
African: 5.8%
East Asian: 3.7%
Hispanic or Latin American: 1%
142,486 individuals (100%)
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • East Asian
  • South Asian
4,498 individuals (100%)
PGS Evaluation
African: 20%
Hispanic or Latin American: 20%
East Asian: 20%
European: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005212
Europe PMC: 29273806
 8,204 individuals African unspecified, African American or Afro-Caribbean NR
GWAS Catalog: GCST005212
Europe PMC: 29273806
 127,669 individuals European NR
GWAS Catalog: GCST005212
Europe PMC: 29273806
 5,215 individuals East Asian NR
GWAS Catalog: GCST005212
Europe PMC: 29273806
 1,398 individuals Hispanic or Latin American NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 1,324 cases
  • , 3,174 controls
]
 European, African unspecified, Hispanic or Latin American, East Asian, South Asian eMERGE — — — Hispanic = Admixed American —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014754 PSS009885|
East Asian Ancestry|
1,671 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.32 [0.99, 1.77] AUROC: 0.73 [0.66, 0.8] R²: 0.08 — —
PPM014755 PSS009887|
South Asian Ancestry|
8,736 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.32 [1.18, 1.48] AUROC: 0.65 [0.62, 0.68] R²: 0.03 — —
PPM014752 PSS009884|
African Ancestry|
7,818 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.43 [1.24, 1.65] AUROC: 0.66 [0.63, 0.69] R²: 0.03 — —
PPM014753 PSS009888|
Hispanic or Latin American Ancestry|
5,225 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.63 [1.36, 1.95] AUROC: 0.7 [0.67, 0.74] R²: 0.07 — —
PPM014751 PSS009886|
European Ancestry|
391,820 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.57 [1.55, 1.6] AUROC: 0.66 [0.65, 0.67] R²: 0.04 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009884 — —
[
  • 310 cases
  • , 7,508 controls
]
 — African unspecified — UKB —
PSS009885 — —
[
  • 49 cases
  • , 1,622 controls
]
 — East Asian — UKB —
PSS009886 — —
[
  • 15,586 cases
  • , 376,234 controls
]
 — European — UKB —
PSS009887 — —
[
  • 312 cases
  • , 8,424 controls
]
 — South Asian — UKB —
PSS009888 — —
[
  • 205 cases
  • , 5,020 controls
]
 — Hispanic or Latin American
(Admixed American)		 — UKB —