Trait: childhood onset asthma

Trait Information
Identifier MONDO_0005405
Description Asthma that starts in childhood. [EFO: 0004591]
Trait category
Other disease
Synonyms 4 synonyms
  • asthma of childhood
  • childhood asthma
  • paediatric asthma
  • pediatric asthma
Mapped terms 4 mapped terms
  • DOID:0080815
  • MEDGEN:538550
  • SCTID:233678006
  • UMLS:C0264408

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002248
(PRSice_asthma)
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Childhood asthma childhood onset asthma 105
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002248/ScoringFiles/PGS002248.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012792 PGS002248
(PRSice_asthma)
 PSS009557|
European Ancestry|
898 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 11 — AUROC: 0.61 — — —
PPM012793 PGS002248
(PRSice_asthma)
 PSS009558|
European Ancestry|
1,018 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 8 — AUROC: 0.65 [0.53, 0.77] — CAPE model —
PPM012791 PGS002248
(PRSice_asthma)
 PSS009558|
European Ancestry|
1,018 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 8 — AUROC: 0.61 — — —
PPM012794 PGS002248
(PRSice_asthma)
 PSS009557|
European Ancestry|
898 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 11 — AUROC: 0.71 [0.61, 0.8] — CAPE model —
PPM012795 PGS002248
(PRSice_asthma)
 PSS009558|
European Ancestry|
1,018 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 8 — AUROC: 0.85 [0.77, 0.92] — CAPP model —
PPM012796 PGS002248
(PRSice_asthma)
 PSS009557|
European Ancestry|
898 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 11 — AUROC: 0.81 [0.72, 0.89] — CAPP model —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009558 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last —
[
  • 144 cases
  • , 874 controls
]
 — European — MAAS —
PSS009557 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last —
[
  • 116 cases
  • , 782 controls
]
 — European — MAAS —