Polygenic Score (PGS) ID: PGS004252

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name PRS212_asthma
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 212
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000544
Citation (link to publication) Zhu Y et al. Ecotoxicol Environ Saf (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
303,859 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST010042
Europe PMC: 32296059
 303,859 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020318 PSS011331|
European Ancestry|
298,738 individuals
 PGP000544 |
Zhu Y et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident asthma HR: 1.59 [1.5, 1.69] — — age, sex, region, employment status, household income, educational level, Townsend deprivation index, smoking status, drinking status, diet, and physical activity, relatedness, number of alleles included in the polygenic risk score, and first 20 principal components of ancestry —
PPM021390 PSS011723|
European Ancestry|
327,124 individuals
 PGP000651 |
Liang H et al. ERJ Open Res (2023)
|Ext.		 Reported Trait: Incident asthma — — Hazard ratio (HR, high vs low PRS tertile): 1.59 [1.5, 1.73] Age, sex, education, Townsend Index, alcohol status, region, relatedness, number of alleles included in the polygenic risk score, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011723 — —
[
  • 6,238 cases
  • , 320,886 controls
]
,
48.1 % Male samples
 Mean = 56.6 years
Sd = 8.03 years		 European — UKB —
PSS011331 — —
[
  • 5,725 cases
  • , 293,013 controls
]
,
48.2 % Male samples
 Mean = 56.62 years
Sd = 8.03 years		 European
(Irish, British)		 — UKB —