PGS Publication: PGP000651

Publication Information (EuropePMC)
Title Association of genetic risk and lifestyle with incident adult-onset asthma in the UK Biobank cohort.
PubMed ID 37057096(Europe PMC)
doi 10.1183/23120541.00499-2022
Publication Date March 1, 2023
Journal ERJ Open Res
Author(s) Liang H, Jing D, Zhu Y, Li D, Zhou X, Tu W, Liu H, Pan P, Zhang Y.
Released in PGS Catalog: June 27, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004252
(PRS212_asthma)
 PGP000544 |
Zhu Y et al. Ecotoxicol Environ Saf (2023)
 Asthma asthma 212
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004252/ScoringFiles/PGS004252.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021390 PGS004252
(PRS212_asthma)
 PSS011723|
European Ancestry|
327,124 individuals
 PGP000651 |
Liang H et al. ERJ Open Res (2023)
|Ext.		 Reported Trait: Incident asthma — — Hazard ratio (HR, high vs low PRS tertile): 1.59 [1.5, 1.73] Age, sex, education, Townsend Index, alcohol status, region, relatedness, number of alleles included in the polygenic risk score, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011723 — —
[
  • 6,238 cases
  • , 320,886 controls
]
,
48.1 % Male samples
 Mean = 56.6 years
Sd = 8.03 years		 European — UKB —