PGS Publication: PGP000704

Publication Information (EuropePMC)
Title Assessment of polygenic risk score performance in East Asian populations for ten common diseases.
PubMed ID 40045046(Europe PMC)
doi 10.1038/s42003-025-07767-9
Publication Date March 6, 2025
Journal Commun Biol
Author(s) Jung HU, Jung H, Baek EJ, Kang JO, Kwon SY, You J, Lim JE, Oh B.
Released in PGS Catalog: March 17, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005148
(Asthma (PRS-CSx; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Asthma asthma 792,583
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005148/ScoringFiles/PGS005148.txt.gz
PGS005154
(Obesity (CT-SLEB; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Obesity obesity 443,124
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005154/ScoringFiles/PGS005154.txt.gz
PGS005145
(Obesity (PRS-CS; EAS))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Obesity obesity 908,466
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005145/ScoringFiles/PGS005145.txt.gz
PGS005151
(Colon polyp (CT-SLEB; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Colon polyp polyp of colon 496,139
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005151/ScoringFiles/PGS005151.txt.gz
PGS005157
(Type 2 diabetes (CT-SLEB; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 502,115
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005157/ScoringFiles/PGS005157.txt.gz
PGS005142
(Cataract (PRS-CS; EAS))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Cataract cataract 908,465
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005142/ScoringFiles/PGS005142.txt.gz
PGS005143
(Coronary artery disease (PRS-CS; EAS))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Coronary artery disease coronary artery disease 943,274
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005143/ScoringFiles/PGS005143.txt.gz
PGS005144
(Hypertension (PRS-CS; EAS))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Hypertension hypertension 908,466
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005144/ScoringFiles/PGS005144.txt.gz
PGS005146
(Osteoporosis (PRS-CS; EAS))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Osteoporosis osteoporosis 908,465
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005146/ScoringFiles/PGS005146.txt.gz
PGS005147
(Type 2 diabetes (PRS-CS; EAS))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 908,465
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005147/ScoringFiles/PGS005147.txt.gz
PGS005149
(Cataract (PRS-CSx; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Cataract cataract 908,465
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005149/ScoringFiles/PGS005149.txt.gz
PGS005150
(Cholelithiasis (PRS-CSx; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Cholelithiasis cholelithiasis 908,465
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005150/ScoringFiles/PGS005150.txt.gz
PGS005141
(Asthma (PRS-CS; EAS))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Asthma asthma 792,583
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005141/ScoringFiles/PGS005141.txt.gz
PGS005152
(Coronary artery disease (PRS-CSx; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Coronary artery disease coronary artery disease 943,274
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005152/ScoringFiles/PGS005152.txt.gz
PGS005153
(Hypertension (CT-SLEB; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Hypertension hypertension 492,555
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005153/ScoringFiles/PGS005153.txt.gz
PGS005155
(Osteoporosis (PRS-CSx; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Osteoporosis osteoporosis 908,465
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005155/ScoringFiles/PGS005155.txt.gz
PGS005156
(Stroke (PRS-CSx; EAS+EUR))
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Stroke stroke 908,465
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005156/ScoringFiles/PGS005156.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022370 PGS005150
(Cholelithiasis (PRS-CSx; EAS+EUR))
 PSS011920|
East Asian Ancestry|
58,628 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Cholelithiasis β: 1.19056 — — age, sex —
PPM022369 PGS005149
(Cataract (PRS-CSx; EAS+EUR))
 PSS011926|
East Asian Ancestry|
58,629 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Cataract β: 1.08426 — — age, sex —
PPM022361 PGS005141
(Asthma (PRS-CS; EAS))
 PSS011924|
East Asian Ancestry|
58,621 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Asthma β: 1.27075 — — age, sex —
PPM022362 PGS005142
(Cataract (PRS-CS; EAS))
 PSS011926|
East Asian Ancestry|
58,629 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Cataract β: 1.08231 — — age, sex —
PPM022363 PGS005143
(Coronary artery disease (PRS-CS; EAS))
 PSS011925|
East Asian Ancestry|
58,625 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Coronary artery disease β: 1.27561 — — age, sex —
PPM022364 PGS005144
(Hypertension (PRS-CS; EAS))
 PSS011921|
East Asian Ancestry|
37,185 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Hypertension β: 1.71261 — — age, sex —
PPM022365 PGS005145
(Obesity (PRS-CS; EAS))
 PSS011928|
East Asian Ancestry|
58,688 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Obesity β: 1.60818 — — age, sex —
PPM022366 PGS005146
(Osteoporosis (PRS-CS; EAS))
 PSS011922|
East Asian Ancestry|
58,611 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Osteoporosis β: 1.09366 — — age, sex —
PPM022367 PGS005147
(Type 2 diabetes (PRS-CS; EAS))
 PSS011923|
East Asian Ancestry|
47,738 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Type 2 diabetes β: 2.16063 — — age, sex —
PPM022368 PGS005148
(Asthma (PRS-CSx; EAS+EUR))
 PSS011924|
East Asian Ancestry|
58,621 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Asthma β: 1.30989 — — age, sex —
PPM022371 PGS005151
(Colon polyp (CT-SLEB; EAS+EUR))
 PSS011927|
East Asian Ancestry|
58,612 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Colon polyp β: 1.15146 — — age, sex —
PPM022372 PGS005152
(Coronary artery disease (PRS-CSx; EAS+EUR))
 PSS011925|
East Asian Ancestry|
58,625 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Coronary artery disease β: 1.30833 — — age, sex —
PPM022373 PGS005153
(Hypertension (CT-SLEB; EAS+EUR))
 PSS011921|
East Asian Ancestry|
37,185 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Hypertension β: 2.03809 — — age, sex —
PPM022374 PGS005154
(Obesity (CT-SLEB; EAS+EUR))
 PSS011928|
East Asian Ancestry|
58,688 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Obesity β: 1.76188 — — age, sex —
PPM022375 PGS005155
(Osteoporosis (PRS-CSx; EAS+EUR))
 PSS011922|
East Asian Ancestry|
58,611 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Osteoporosis β: 1.14434 — — age, sex —
PPM022376 PGS005156
(Stroke (PRS-CSx; EAS+EUR))
 PSS011929|
East Asian Ancestry|
58,633 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Stroke β: 1.17852 — — age, sex —
PPM022377 PGS005157
(Type 2 diabetes (CT-SLEB; EAS+EUR))
 PSS011923|
East Asian Ancestry|
47,738 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Type 2 diabetes β: 2.32703 — — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011920 — —
[
  • 1,784 cases
  • , 56,844 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011921 — —
[
  • 17,073 cases
  • , 20,112 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011922 — —
[
  • 3,074 cases
  • , 55,537 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011923 — —
[
  • 4,982 cases
  • , 42,756 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011924 — —
[
  • 977 cases
  • , 57,644 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011925 — —
[
  • 3,336 cases
  • , 55,276 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011926 — —
[
  • 2,070 cases
  • , 56,559 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011927 — —
[
  • 3,336 cases
  • , 55,276 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011928 — —
[
  • 18,895 cases
  • , 39,793 controls
]
 — East Asian
(Korean)		 — HEXA —
PSS011929 — —
[
  • 693 cases
  • , 57,940 controls
]
 — East Asian
(Korean)		 — HEXA —