Polygenic Score (PGS) ID: PGS005156

Predicted Trait
Reported Trait Stroke
Mapped Trait(s) stroke (EFO_0000712)
Released in PGS Catalog: March 17, 2025
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Score Details

Score Construction
PGS Name Stroke (PRS-CSx; EAS+EUR)
Development Method
Name PRS-CSx
Parameters PRS-CSx auto
Variants
Original Genome Build hg19
Number of Variants 908,465
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000704
Citation (link to publication) Jung HU et al. Commun Biol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 71.9%
East Asian: 28.1%
621,382 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90018644
Europe PMC: 34594039
 174,686 individuals East Asian BBJ
GWAS Catalog: GCST006906
Europe PMC: 29531354
[
  • 40,585 cases
  • , 406,111 controls
]
 European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022376 PSS011929|
East Asian Ancestry|
58,633 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Stroke β: 1.17852 — — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011929 — —
[
  • 693 cases
  • , 57,940 controls
]
 — East Asian
(Korean)		 — HEXA —