Polygenic Score (PGS) ID: PGS005149

Predicted Trait
Reported Trait Cataract
Mapped Trait(s) cataract (MONDO_0005129)
Released in PGS Catalog: March 17, 2025
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name Cataract (PRS-CSx; EAS+EUR)
Development Method
Name PRS-CSx
Parameters PRS-CSx auto
Variants
Original Genome Build hg19
Number of Variants 908,465
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000704
Citation (link to publication) Jung HU et al. Commun Biol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 71.9%
East Asian: 28.1%
635,074 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST90018594
Europe PMC: 34594039
178,726 individualsEast AsianBBJ
GWAS Catalog: GCST90043785
Europe PMC: 34737426
456,348 individualsEuropeanUKB
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM022369PSS011926|
East Asian Ancestry|
58,629 individuals
PGP000704 |
Jung HU et al. Commun Biol (2025)
Reported Trait: Cataractβ: 1.08426——age, sex—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011926——
[
  • 2,070 cases
  • , 56,559 controls
]
—East Asian
(Korean)		—HEXA—
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