Polygenic Score (PGS) ID: PGS005151

Predicted Trait
Reported Trait Colon polyp
Mapped Trait(s) polyp of colon (MONDO_0021400)
Released in PGS Catalog: March 17, 2025
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Score Details

Score Construction
PGS Name Colon polyp (CT-SLEB; EAS+EUR)
Development Method
Name CT-SLEB
Parameters SNP r2 threshold: 0.05, window size (kb) 2000, P-value threshold: 5.00E-07
Variants
Original Genome Build hg19
Number of Variants 496,139
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000704
Citation (link to publication) Jung HU et al. Commun Biol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 72.8%
East Asian: 27.2%
627,168 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90018607
Europe PMC: 34594039
 170,820 individuals East Asian BBJ
Europe PMC: 34737426
[
  • 19,026 cases
  • , 437,322 controls
]
 European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022371 PSS011927|
East Asian Ancestry|
58,612 individuals
 PGP000704 |
Jung HU et al. Commun Biol (2025)
 Reported Trait: Colon polyp β: 1.15146 — — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011927 — —
[
  • 3,336 cases
  • , 55,276 controls
]
 — East Asian
(Korean)		 — HEXA —