| Publication Information (EuropePMC) | |
| Title | Genetic risk scores do not improve asthma prediction in childhood. |
| PubMed ID | 31145937(Europe PMC) |
| doi | 10.1016/j.jaci.2019.05.017 |
| Publication Date | May 27, 2019 |
| Journal | J Allergy Clin Immunol |
| Author(s) | Dijk FN, Folkersma C, Gruzieva O, Kumar A, Wijga AH, Gehring U, Kull I, Postma DS, Vonk JM, Melén E, Koppelman GH. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000800 (GRSw_SHARE) |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Allergic disease | allergic disease | 133 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000800/ScoringFiles/PGS000800.txt.gz |
| PGS000799 (GRSw_TAGC) |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Asthma | asthma | 22 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000799/ScoringFiles/PGS000799.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM002081 | PGS000800 (GRSw_SHARE) |
PSS001029| European Ancestry| 1,858 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | OR: 1.72 [1.21, 2.44] | — | — | — | — |
| PPM002083 | PGS000800 (GRSw_SHARE) |
PSS001028| European Ancestry| 427 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | OR: 4.75 | — | — | — | — |
| PPM002079 | PGS000799 (GRSw_TAGC) |
PSS001028| European Ancestry| 427 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | OR: 1.52 [1.19, 1.96] | — | — | — | Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data. |
| PPM002077 | PGS000799 (GRSw_TAGC) |
PSS001029| European Ancestry| 1,858 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | OR: 1.23 [1.1, 1.38] | — | — | — | — |
| PPM002078 | PGS000799 (GRSw_TAGC) |
PSS001029| European Ancestry| 1,858 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | — | AUROC: 0.66 | — | Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) | — |
| PPM002080 | PGS000799 (GRSw_TAGC) |
PSS001028| European Ancestry| 427 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | — | AUROC: 0.69 | — | Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) | Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data. |
| PPM002082 | PGS000800 (GRSw_SHARE) |
PSS001029| European Ancestry| 1,858 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | — | AUROC: 0.65 | — | Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) | — |
| PPM002084 | PGS000800 (GRSw_SHARE) |
PSS001028| European Ancestry| 427 individuals |
PGP000189 | Dijk FN et al. J Allergy Clin Immunol (2019) |
Reported Trait: Asthma ever, at age 8 years | — | AUROC: 0.7 | — | Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS001028 | Cases were children with asthma ever, at age 8 years. Cases were defined using an adjusted diagnosis of asthma ever at age 8 years based on (1) 1 or more attacks of wheeze in the last 12 months or (2) inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had at least 1 of these characteristics was categorized as having asthma. | — | [ ,
56.2 % Male samples |
— | European (Swedish) |
— | BAMSE | Possible sample overlap of up to 100% between this dataset and the datasets used to source variants for GRSw_TAGC. |
| PSS001029 | Cases were children with asthma ever, at age 8 years, in which asthma was defined by the following characteristics: 1 or more attacks of wheeze in the last 12 months, 1 or more events of shortness of breath (dyspnea) in the last 12 months, or inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had 1 or more of these characteristics was categorized as having asthma. | — | [ ,
51.1 % Male samples |
— | European | — | PIAMA | Possible sample overlap of up to 19% between this dataset and the datasets used to source variants for GRSw_TAGC. |