Polygenic Score (PGS) ID: PGS005130

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Released in PGS Catalog: Feb. 4, 2025
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Score Details

Score Construction
PGS Name forEAS_fromSAS
Development Method
Name PRS-CSx
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 708,315
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000703
Citation (link to publication) Tsuo K et al. Cell Genom (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (excluding European): 100%
  • Additional Asian Ancestries
  • South Asian
31,106 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 4,015 cases
  • , 27,091 controls
]
 Central Asian, South Asian G&H, UCLA, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022350 PSS011917|
East Asian Ancestry|
1,000 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05266 age, sex, 20 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011917 — —
[
  • 500 cases
  • , 500 controls
]
 — East Asian — BBJ —