PGS Publication: PGP000703

Publication Information (EuropePMC)
Title Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity.
PubMed ID 36778051(Europe PMC)
doi 10.1016/j.xgen.2022.100212
Publication Date Nov. 8, 2022
Journal Cell Genom
Author(s) Tsuo K, Zhou W, Wang Y, Kanai M, Namba S, Gupta R, Majara L, Nkambule LL, Morisaki T, Okada Y, Neale BM, Global Biobank Meta-analysis Initiative, Daly MJ, Martin AR.
Released in PGS Catalog: Feb. 4, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005140
(forSAS_fromSAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 904,126
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005140/ScoringFiles/PGS005140.txt.gz
PGS005135
(forEUR_fromSAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 923,118
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005135/ScoringFiles/PGS005135.txt.gz
PGS005134
(forEUR_fromEUR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 909,298
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005134/ScoringFiles/PGS005134.txt.gz
PGS005129
(forEAS_fromEUR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 692,328
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005129/ScoringFiles/PGS005129.txt.gz
PGS005128
(forEAS_fromEAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 711,650
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005128/ScoringFiles/PGS005128.txt.gz
PGS005127
(forEAS_fromAMR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 711,987
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005127/ScoringFiles/PGS005127.txt.gz
PGS005126
(forEAS_fromAFR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 699,919
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005126/ScoringFiles/PGS005126.txt.gz
PGS005125
(forAFR_fromSAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 922,758
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005125/ScoringFiles/PGS005125.txt.gz
PGS005124
(forAFR_fromEUR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 909,301
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005124/ScoringFiles/PGS005124.txt.gz
PGS005130
(forEAS_fromSAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 708,315
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005130/ScoringFiles/PGS005130.txt.gz
PGS005136
(forSAS_fromAFR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 982,014
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005136/ScoringFiles/PGS005136.txt.gz
PGS005122
(forAFR_fromAMR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 965,078
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005122/ScoringFiles/PGS005122.txt.gz
PGS005123
(forAFR_fromEAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 835,583
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005123/ScoringFiles/PGS005123.txt.gz
PGS005131
(forEUR_fromAFR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 1,005,883
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005131/ScoringFiles/PGS005131.txt.gz
PGS005132
(forEUR_fromAMR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 965,696
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005132/ScoringFiles/PGS005132.txt.gz
PGS005137
(forSAS_fromAMR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 965,403
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005137/ScoringFiles/PGS005137.txt.gz
PGS005138
(forSAS_fromEAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 837,039
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005138/ScoringFiles/PGS005138.txt.gz
PGS005121
(forAFR_fromAFR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 1,008,855
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005121/ScoringFiles/PGS005121.txt.gz
PGS005133
(forEUR_fromEAS)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 837,079
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005133/ScoringFiles/PGS005133.txt.gz
PGS005139
(forSAS_fromEUR)
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Asthma asthma 909,320
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005139/ScoringFiles/PGS005139.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022341 PGS005121
(forAFR_fromAFR)
 PSS011916|
African Ancestry|
6,039 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.01355 age, sex, 20 genetic principal components —
PPM022342 PGS005122
(forAFR_fromAMR)
 PSS011916|
African Ancestry|
6,039 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.01355 age, sex, 20 genetic principal components —
PPM022343 PGS005123
(forAFR_fromEAS)
 PSS011916|
African Ancestry|
6,039 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.01355 age, sex, 20 genetic principal components —
PPM022344 PGS005124
(forAFR_fromEUR)
 PSS011916|
African Ancestry|
6,039 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.01355 age, sex, 20 genetic principal components —
PPM022345 PGS005125
(forAFR_fromSAS)
 PSS011916|
African Ancestry|
6,039 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.01355 age, sex, 20 genetic principal components —
PPM022346 PGS005126
(forEAS_fromAFR)
 PSS011917|
East Asian Ancestry|
1,000 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05266 age, sex, 20 genetic principal components —
PPM022347 PGS005127
(forEAS_fromAMR)
 PSS011917|
East Asian Ancestry|
1,000 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05266 age, sex, 20 genetic principal components —
PPM022348 PGS005128
(forEAS_fromEAS)
 PSS011917|
East Asian Ancestry|
1,000 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05266 age, sex, 20 genetic principal components —
PPM022349 PGS005129
(forEAS_fromEUR)
 PSS011917|
East Asian Ancestry|
1,000 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05266 age, sex, 20 genetic principal components —
PPM022350 PGS005130
(forEAS_fromSAS)
 PSS011917|
East Asian Ancestry|
1,000 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05266 age, sex, 20 genetic principal components —
PPM022351 PGS005131
(forEUR_fromAFR)
 PSS011918|
European Ancestry|
8,741 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05358 age, sex, 20 genetic principal components —
PPM022352 PGS005132
(forEUR_fromAMR)
 PSS011918|
European Ancestry|
8,741 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05358 age, sex, 20 genetic principal components —
PPM022353 PGS005133
(forEUR_fromEAS)
 PSS011918|
European Ancestry|
8,741 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05358 age, sex, 20 genetic principal components —
PPM022354 PGS005134
(forEUR_fromEUR)
 PSS011918|
European Ancestry|
8,741 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05358 age, sex, 20 genetic principal components —
PPM022355 PGS005135
(forEUR_fromSAS)
 PSS011918|
European Ancestry|
8,741 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.05358 age, sex, 20 genetic principal components —
PPM022356 PGS005136
(forSAS_fromAFR)
 PSS011919|
Multi-ancestry (excluding European)|
7,976 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.03767 age, sex, 20 genetic principal components —
PPM022357 PGS005137
(forSAS_fromAMR)
 PSS011919|
Multi-ancestry (excluding European)|
7,976 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.03767 age, sex, 20 genetic principal components —
PPM022358 PGS005138
(forSAS_fromEAS)
 PSS011919|
Multi-ancestry (excluding European)|
7,976 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.03767 age, sex, 20 genetic principal components —
PPM022359 PGS005139
(forSAS_fromEUR)
 PSS011919|
Multi-ancestry (excluding European)|
7,976 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.03767 age, sex, 20 genetic principal components —
PPM022360 PGS005140
(forSAS_fromSAS)
 PSS011919|
Multi-ancestry (excluding European)|
7,976 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.03767 age, sex, 20 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011916 — —
[
  • 849 cases
  • , 5,190 controls
]
 — African unspecified — UKB —
PSS011917 — —
[
  • 500 cases
  • , 500 controls
]
 — East Asian — BBJ —
PSS011918 — —
[
  • 1,164 cases
  • , 7,577 controls
]
 — European — UKB —
PSS011919 — —
[
  • 1,232 cases
  • , 6,744 controls
]
 — Central Asian, South Asian — UKB —