Polygenic Score (PGS) ID: PGS001848

Predicted Trait
Reported Trait Nasal polyps
Mapped Trait(s) Nasal polyposis (HP_0100582)
Additional Trait Information respiratory
Released in PGS Catalog: Jan. 10, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-PLR_471
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 1,783
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
East Asian: 30%
European: 30%
African: 20%
Greater Middle Eastern: 10%
South Asian: 10%
10 Sample Sets

Development Samples

Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—391,124 individualsEuropeanUKB———UK (+ Ireland)—
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM009674PSS009323|
European Ancestry|
19,106 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): 0.0469 [0.0327, 0.0611]sex, age, birth date, deprivation index, 16 PCs—
PPM009675PSS009097|
European Ancestry|
3,952 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): 0.0653 [0.0341, 0.0963]sex, age, birth date, deprivation index, 16 PCs—
PPM009676PSS008651|
European Ancestry|
6,357 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): 0.0455 [0.0209, 0.07]sex, age, birth date, deprivation index, 16 PCs—
PPM009677PSS008425|
Greater Middle Eastern Ancestry|
1,114 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): 0.0094 [-0.0499, 0.0686]sex, age, birth date, deprivation index, 16 PCs—
PPM009678PSS008205|
South Asian Ancestry|
6,007 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): 0.0287 [0.0034, 0.054]sex, age, birth date, deprivation index, 16 PCs—
PPM009679PSS007987|
East Asian Ancestry|
1,740 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): 0.0006 [-0.0467, 0.0478]sex, age, birth date, deprivation index, 16 PCs—
PPM009680PSS007770|
African Ancestry|
2,365 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): -0.011 [-0.0514, 0.0295]sex, age, birth date, deprivation index, 16 PCs—
PPM009681PSS008874|
African Ancestry|
3,758 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Nasal polyps——Partial Correlation (partial-r): 0.0034 [-0.0286, 0.0355]sex, age, birth date, deprivation index, 16 PCs—
PPM022197PSS011841|
East Asian Ancestry|
5,885 individuals
PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		Reported Trait: Chronic rhinosinusitis—AUROC: 0.533 [0.507, 0.56]———
PPM022201PSS011842|
East Asian Ancestry|
535 individuals
PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis—AUROC: 0.58 [0.527, 0.632]———
PPM022203PSS011841|
East Asian Ancestry|
5,885 individuals
PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		Reported Trait: Chronic rhinosinusitis——Odds ratio (OR, high vs low PGS quartile): 1.352 [1.058, 1.729]——
PPM022205PSS011842|
East Asian Ancestry|
535 individuals
PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis——Odds ratio (OR, high vs low PGS quartile): 1.92 [1.147, 3.212]——
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS007770——2,365 individuals—African American or Afro-CaribbeanCarribeanUKB—
PSS007987——1,740 individuals—East AsianChina (East Asia)UKB—
PSS008205——6,007 individuals—South AsianIndia (South Asia)UKB—
PSS008425——1,114 individuals—Greater Middle Eastern (Middle Eastern, North African or Persian)Iran (Middle East)UKB—
PSS008651——6,357 individuals—EuropeanItaly (South Europe)UKB—
PSS008874——3,758 individuals—African unspecifiedNigeria (West Africa)UKB—
PSS009097——3,952 individuals—EuropeanPoland (NE Europe)UKB—
PSS009323——19,106 individuals—EuropeanUK (+ Ireland)UKB—
PSS011841——
[
  • 535 cases
  • , 5,350 controls
]
—East Asian
(Taiwanese)		—TPMI—
PSS011842——
[
  • 172 cases
  • , 363 controls
]
—East Asian
(Taiwanese)		—TPMI—
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