PGS Publication: PGP000690

Publication Information (EuropePMC)
Title Risk Prediction of Chronic Rhinosinusitis with or without Nasal Polyps in Taiwanese Population Using Polygenic Risk Score for Nasal Polyps.
PubMed ID 37893103(Europe PMC)
doi 10.3390/biomedicines11102729
Publication Date Oct. 9, 2023
Journal Biomedicines
Author(s) Jiang RS, Chen IC, Chen YM, Hsiao TH, Chen YC.
Released in PGS Catalog: Nov. 21, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001848
(portability-PLR_471)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Nasal polyps Nasal polyposis 1,783
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001848/ScoringFiles/PGS001848.txt.gz
PGS002060
(portability-ldpred2_471)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Nasal polyps Nasal polyposis 553,242
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002060/ScoringFiles/PGS002060.txt.gz
PGS000933
(GBE_HC1024)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Nasal polyp (time-to-event) Nasal polyposis 433
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000933/ScoringFiles/PGS000933.txt.gz
PGS000934
(GBE_HC156)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Nasal polyps Nasal polyposis 129
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000934/ScoringFiles/PGS000934.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022195 PGS000933
(GBE_HC1024)
 PSS011841|
East Asian Ancestry|
5,885 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Chronic rhinosinusitis — AUROC: 0.533 [0.507, 0.56] — — —
PPM022196 PGS000934
(GBE_HC156)
 PSS011841|
East Asian Ancestry|
5,885 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Chronic rhinosinusitis — AUROC: 0.531 [0.505, 0.556] — — —
PPM022197 PGS001848
(portability-PLR_471)
 PSS011841|
East Asian Ancestry|
5,885 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Chronic rhinosinusitis — AUROC: 0.533 [0.507, 0.56] — — —
PPM022198 PGS002060
(portability-ldpred2_471)
 PSS011841|
East Asian Ancestry|
5,885 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Chronic rhinosinusitis — AUROC: 0.534 [0.508, 0.56] — — —
PPM022199 PGS000933
(GBE_HC1024)
 PSS011842|
East Asian Ancestry|
535 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis — AUROC: 0.532 [0.481, 0.583] — — —
PPM022200 PGS000934
(GBE_HC156)
 PSS011842|
East Asian Ancestry|
535 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis — AUROC: 0.517 [0.465, 0.569] — — —
PPM022201 PGS001848
(portability-PLR_471)
 PSS011842|
East Asian Ancestry|
535 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis — AUROC: 0.58 [0.527, 0.632] — — —
PPM022202 PGS002060
(portability-ldpred2_471)
 PSS011842|
East Asian Ancestry|
535 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis — AUROC: 0.588 [0.537, 0.64] — — —
PPM022203 PGS001848
(portability-PLR_471)
 PSS011841|
East Asian Ancestry|
5,885 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Chronic rhinosinusitis — — Odds ratio (OR, high vs low PGS quartile): 1.352 [1.058, 1.729] — —
PPM022204 PGS002060
(portability-ldpred2_471)
 PSS011841|
East Asian Ancestry|
5,885 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Chronic rhinosinusitis — — Odds ratio (OR, high vs low PGS quartile): 1.477 [1.142, 1.91] — —
PPM022205 PGS001848
(portability-PLR_471)
 PSS011842|
East Asian Ancestry|
535 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis — — Odds ratio (OR, high vs low PGS quartile): 1.92 [1.147, 3.212] — —
PPM022206 PGS002060
(portability-ldpred2_471)
 PSS011842|
East Asian Ancestry|
535 individuals
 PGP000690 |
Jiang RS et al. Biomedicines (2023)
|Ext.		 Reported Trait: Nasal polyps in individuals with chronic rhinosinusitis — — Odds ratio (OR, high vs low PGS quartile): 2.318 [1.371, 3.921] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011841 — —
[
  • 535 cases
  • , 5,350 controls
]
 — East Asian
(Taiwanese)		 — TPMI —
PSS011842 — —
[
  • 172 cases
  • , 363 controls
]
 — East Asian
(Taiwanese)		 — TPMI —