Polygenic Score (PGS) ID: PGS001916

Predicted Trait
Reported Trait Falls in the last year
Mapped Trait(s) fall (EFO_0009631)
Additional Trait Information injuries & poisonings
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_fall_1y
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 9,917
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010211 PSS009404|
European Ancestry|
19,947 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0228 [0.0089, 0.0366] sex, age, birth date, deprivation index, 16 PCs —
PPM010212 PSS009178|
European Ancestry|
4,070 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0369 [0.0061, 0.0676] sex, age, birth date, deprivation index, 16 PCs —
PPM010213 PSS008732|
European Ancestry|
6,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0428 [0.0187, 0.0669] sex, age, birth date, deprivation index, 16 PCs —
PPM010214 PSS008506|
Greater Middle Eastern Ancestry|
1,089 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0845 [0.0246, 0.1437] sex, age, birth date, deprivation index, 16 PCs —
PPM010215 PSS008284|
South Asian Ancestry|
6,030 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.019 [-0.0063, 0.0442] sex, age, birth date, deprivation index, 16 PCs —
PPM010216 PSS008061|
East Asian Ancestry|
1,755 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0303 [-0.0167, 0.0773] sex, age, birth date, deprivation index, 16 PCs —
PPM010217 PSS007848|
African Ancestry|
2,437 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0163 [-0.0236, 0.0562] sex, age, birth date, deprivation index, 16 PCs —
PPM010218 PSS008952|
African Ancestry|
3,814 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0154 [-0.0165, 0.0472] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007848 — — 2,437 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008732 — — 6,602 individuals — European Italy (South Europe) UKB —
PSS008952 — — 3,814 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008506 — — 1,089 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009178 — — 4,070 individuals — European Poland (NE Europe) UKB —
PSS009404 — — 19,947 individuals — European UK (+ Ireland) UKB —
PSS008061 — — 1,755 individuals — East Asian China (East Asia) UKB —
PSS008284 — — 6,030 individuals — South Asian India (South Asia) UKB —