Trait: fall

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009631
Description A sudden movement downward, usually resulting in injury. [ NCI ]
Trait category
Other trait
Mapped terms 2 mapped terms
  • ICD10:W19
  • NCIt:C50558

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001012
(GBE_QT_FC1002296)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Number of falls in the last year fall 2,103
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001012/ScoringFiles/PGS001012.txt.gz
PGS001916
(portability-PLR_fall_1y)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Falls in the last year fall 9,917
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001916/ScoringFiles/PGS001916.txt.gz
PGS002132
(portability-ldpred2_fall_1y)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Falls in the last year fall 826,502
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002132/ScoringFiles/PGS002132.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007823 PGS001012
(GBE_QT_FC1002296)
 PSS007596|
African Ancestry|
6,336 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Falls in the last year — — Incremental R2 (full-covars): -0.00094
R²: 0.01681 [0.01062, 0.02301]
PGS R2 (no covariates): 3e-05 [-0.00022, 0.00027]		 age, sex, UKB array type, Genotype PCs —
PPM007824 PGS001012
(GBE_QT_FC1002296)
 PSS007597|
East Asian Ancestry|
1,629 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Falls in the last year — — R²: 0.0157 [0.00401, 0.02739]
Incremental R2 (full-covars): -0.00264
PGS R2 (no covariates): 0.00011 [-0.00088, 0.00109]		 age, sex, UKB array type, Genotype PCs —
PPM007825 PGS001012
(GBE_QT_FC1002296)
 PSS007598|
European Ancestry|
24,790 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Falls in the last year — — R²: 0.0119 [0.00923, 0.01458]
Incremental R2 (full-covars): 0.00165
PGS R2 (no covariates): 0.00166 [0.00065, 0.00267]		 age, sex, UKB array type, Genotype PCs —
PPM007826 PGS001012
(GBE_QT_FC1002296)
 PSS007599|
South Asian Ancestry|
7,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Falls in the last year — — R²: 0.01243 [0.00756, 0.01731]
Incremental R2 (full-covars): -0.00079
PGS R2 (no covariates): 0.00021 [-0.00043, 0.00084]		 age, sex, UKB array type, Genotype PCs —
PPM007827 PGS001012
(GBE_QT_FC1002296)
 PSS007600|
European Ancestry|
67,306 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Falls in the last year — — R²: 0.01122 [0.00964, 0.0128]
Incremental R2 (full-covars): 0.00106
PGS R2 (no covariates): 0.00126 [0.00073, 0.0018]		 age, sex, UKB array type, Genotype PCs —
PPM010211 PGS001916
(portability-PLR_fall_1y)
 PSS009404|
European Ancestry|
19,947 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0228 [0.0089, 0.0366] sex, age, birth date, deprivation index, 16 PCs —
PPM010212 PGS001916
(portability-PLR_fall_1y)
 PSS009178|
European Ancestry|
4,070 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0369 [0.0061, 0.0676] sex, age, birth date, deprivation index, 16 PCs —
PPM010213 PGS001916
(portability-PLR_fall_1y)
 PSS008732|
European Ancestry|
6,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0428 [0.0187, 0.0669] sex, age, birth date, deprivation index, 16 PCs —
PPM010214 PGS001916
(portability-PLR_fall_1y)
 PSS008506|
Greater Middle Eastern Ancestry|
1,089 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0845 [0.0246, 0.1437] sex, age, birth date, deprivation index, 16 PCs —
PPM010215 PGS001916
(portability-PLR_fall_1y)
 PSS008284|
South Asian Ancestry|
6,030 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.019 [-0.0063, 0.0442] sex, age, birth date, deprivation index, 16 PCs —
PPM010216 PGS001916
(portability-PLR_fall_1y)
 PSS008061|
East Asian Ancestry|
1,755 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0303 [-0.0167, 0.0773] sex, age, birth date, deprivation index, 16 PCs —
PPM010217 PGS001916
(portability-PLR_fall_1y)
 PSS007848|
African Ancestry|
2,437 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0163 [-0.0236, 0.0562] sex, age, birth date, deprivation index, 16 PCs —
PPM010218 PGS001916
(portability-PLR_fall_1y)
 PSS008952|
African Ancestry|
3,814 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0154 [-0.0165, 0.0472] sex, age, birth date, deprivation index, 16 PCs —
PPM011911 PGS002132
(portability-ldpred2_fall_1y)
 PSS009404|
European Ancestry|
19,947 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0504 [0.0365, 0.0642] sex, age, birth date, deprivation index, 16 PCs —
PPM011912 PGS002132
(portability-ldpred2_fall_1y)
 PSS009178|
European Ancestry|
4,070 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0507 [0.02, 0.0814] sex, age, birth date, deprivation index, 16 PCs —
PPM011913 PGS002132
(portability-ldpred2_fall_1y)
 PSS008732|
European Ancestry|
6,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0625 [0.0384, 0.0865] sex, age, birth date, deprivation index, 16 PCs —
PPM011914 PGS002132
(portability-ldpred2_fall_1y)
 PSS008506|
Greater Middle Eastern Ancestry|
1,089 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0693 [0.0093, 0.1287] sex, age, birth date, deprivation index, 16 PCs —
PPM011915 PGS002132
(portability-ldpred2_fall_1y)
 PSS008284|
South Asian Ancestry|
6,030 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0393 [0.014, 0.0645] sex, age, birth date, deprivation index, 16 PCs —
PPM011916 PGS002132
(portability-ldpred2_fall_1y)
 PSS008061|
East Asian Ancestry|
1,755 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0553 [0.0083, 0.1021] sex, age, birth date, deprivation index, 16 PCs —
PPM011917 PGS002132
(portability-ldpred2_fall_1y)
 PSS007848|
African Ancestry|
2,437 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0471 [0.0073, 0.0868] sex, age, birth date, deprivation index, 16 PCs —
PPM011918 PGS002132
(portability-ldpred2_fall_1y)
 PSS008952|
African Ancestry|
3,814 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Falls in the last year — — Partial Correlation (partial-r): 0.0523 [0.0206, 0.084] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007848 — — 2,437 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008732 — — 6,602 individuals — European Italy (South Europe) UKB —
PSS007596 — — 6,336 individuals — African unspecified — UKB —
PSS007597 — — 1,629 individuals — East Asian — UKB —
PSS007598 — — 24,790 individuals — European non-white British ancestry UKB —
PSS007599 — — 7,443 individuals — South Asian — UKB —
PSS007600 — — 67,306 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS008952 — — 3,814 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009178 — — 4,070 individuals — European Poland (NE Europe) UKB —
PSS008506 — — 1,089 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009404 — — 19,947 individuals — European UK (+ Ireland) UKB —
PSS008061 — — 1,755 individuals — East Asian China (East Asia) UKB —
PSS008284 — — 6,030 individuals — South Asian India (South Asia) UKB —