PGS Catalog - PGS002132 / Falls in the last year (Polygenic Score)

Polygenic Score (PGS) ID: PGS002132

Predicted Trait
Reported Trait	Falls in the last year
Mapped Trait(s)	fall (EFO_0009631)
Additional Trait Information	injuries & poisonings

Released in PGS Catalog: Jan. 10, 2022

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Score Details

Score Construction
PGS Name	portability-ldpred2_fall_1y
Development Method
Name	LDpred2 (bigsnpr)
Parameters	LDpred2-auto using HapMap3 variants
Variants
Original Genome Build	GRCh37
Number of Variants	826,502
Effect Weight Type	beta

PGS Source
PGS Catalog Publication (PGP) ID	PGP000263
Citation (link to publication)	Privé F et al. Am J Hum Genet (2022)

Ancestry Distribution
Score Development/Training	European: 100% 391,124 individuals (100%)
PGS Evaluation	European: 37.5% African: 25% East Asian: 12.5% Greater Middle Eastern: 12.5% South Asian: 12.5% 8 Sample Sets

Development Samples

Score Development/Training

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)	Phenotype Definitions & Methods	Age of Study Participants	Participant Follow-up Time	Additional Ancestry Description	Additional Sample/Cohort Information
—	391,124 individuals	European	UKB	—	—	—	UK (+ Ireland)	—

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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM011911	PSS009404\| European Ancestry\| 19,947 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0504 [0.0365, 0.0642]	sex, age, birth date, deprivation index, 16 PCs	—
PPM011912	PSS009178\| European Ancestry\| 4,070 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0507 [0.02, 0.0814]	sex, age, birth date, deprivation index, 16 PCs	—
PPM011913	PSS008732\| European Ancestry\| 6,602 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0625 [0.0384, 0.0865]	sex, age, birth date, deprivation index, 16 PCs	—
PPM011914	PSS008506\| Greater Middle Eastern Ancestry\| 1,089 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0693 [0.0093, 0.1287]	sex, age, birth date, deprivation index, 16 PCs	—
PPM011915	PSS008284\| South Asian Ancestry\| 6,030 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0393 [0.014, 0.0645]	sex, age, birth date, deprivation index, 16 PCs	—
PPM011916	PSS008061\| East Asian Ancestry\| 1,755 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0553 [0.0083, 0.1021]	sex, age, birth date, deprivation index, 16 PCs	—
PPM011917	PSS007848\| African Ancestry\| 2,437 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0471 [0.0073, 0.0868]	sex, age, birth date, deprivation index, 16 PCs	—
PPM011918	PSS008952\| African Ancestry\| 3,814 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: Falls in the last year	—	—	Partial Correlation (partial-r): 0.0523 [0.0206, 0.084]	sex, age, birth date, deprivation index, 16 PCs	—

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Evaluated Samples

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PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS007848	—	—	2,437 individuals	—	African American or Afro-Caribbean	Carribean	UKB	—
PSS008061	—	—	1,755 individuals	—	East Asian	China (East Asia)	UKB	—
PSS008284	—	—	6,030 individuals	—	South Asian	India (South Asia)	UKB	—
PSS008506	—	—	1,089 individuals	—	Greater Middle Eastern (Middle Eastern, North African or Persian)	Iran (Middle East)	UKB	—
PSS008732	—	—	6,602 individuals	—	European	Italy (South Europe)	UKB	—
PSS008952	—	—	3,814 individuals	—	African unspecified	Nigeria (West Africa)	UKB	—
PSS009178	—	—	4,070 individuals	—	European	Poland (NE Europe)	UKB	—
PSS009404	—	—	19,947 individuals	—	European	UK (+ Ireland)	UKB	—

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