Polygenic Score (PGS) ID: PGS002098

Predicted Trait
Reported Trait Recent poor appetite or overeating
Mapped Trait(s) eating disorder (EFO_0005203)
Additional Trait Information symptoms
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_abnormal_appetite
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 764,146
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011640 PSS009381|
European Ancestry|
6,451 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): 0.0629 [0.0385, 0.0872] sex, age, birth date, deprivation index, 16 PCs —
PPM011641 PSS009155|
European Ancestry|
1,243 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): 0.1194 [0.0638, 0.1743] sex, age, birth date, deprivation index, 16 PCs —
PPM011642 PSS008709|
European Ancestry|
2,260 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): 0.0823 [0.0411, 0.1233] sex, age, birth date, deprivation index, 16 PCs —
PPM011644 PSS008261|
South Asian Ancestry|
814 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): 0.0558 [-0.0138, 0.1249] sex, age, birth date, deprivation index, 16 PCs —
PPM011645 PSS008039|
East Asian Ancestry|
427 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): 0.0486 [-0.0488, 0.1451] sex, age, birth date, deprivation index, 16 PCs —
PPM011646 PSS007825|
African Ancestry|
372 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): -0.0014 [-0.1059, 0.1032] sex, age, birth date, deprivation index, 16 PCs —
PPM011647 PSS008929|
African Ancestry|
511 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): -0.014 [-0.1023, 0.0746] sex, age, birth date, deprivation index, 16 PCs —
PPM011643 PSS008483|
Greater Middle Eastern Ancestry|
201 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent poor appetite or overeating — — Partial Correlation (partial-r): 0.1181 [-0.0282, 0.2595] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008709 — — 2,260 individuals — European Italy (South Europe) UKB —
PSS009381 — — 6,451 individuals — European UK (+ Ireland) UKB —
PSS008261 — — 814 individuals — South Asian India (South Asia) UKB —
PSS008039 — — 427 individuals — East Asian China (East Asia) UKB —
PSS008483 — — 201 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS007825 — — 372 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008929 — — 511 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009155 — — 1,243 individuals — European Poland (NE Europe) UKB —