Polygenic Score (PGS) ID: PGS002143

Predicted Trait
Reported Trait Hand grip strength (mean of both)
Mapped Trait(s) grip strength measurement (EFO_0006941)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_hand_grip_strength
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 966,283
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011995 PSS008293|
South Asian Ancestry|
6,223 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.1759 [0.1517, 0.1999] sex, age, birth date, deprivation index, 16 PCs —
PPM011991 PSS009413|
European Ancestry|
19,855 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.262 [0.249, 0.2749] sex, age, birth date, deprivation index, 16 PCs —
PPM011992 PSS009187|
European Ancestry|
4,105 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.2543 [0.2254, 0.2827] sex, age, birth date, deprivation index, 16 PCs —
PPM011993 PSS008741|
European Ancestry|
6,598 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.2433 [0.2204, 0.2659] sex, age, birth date, deprivation index, 16 PCs —
PPM011994 PSS008515|
Greater Middle Eastern Ancestry|
1,168 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.2026 [0.1465, 0.2575] sex, age, birth date, deprivation index, 16 PCs —
PPM011996 PSS008070|
East Asian Ancestry|
1,799 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.1631 [0.1175, 0.208] sex, age, birth date, deprivation index, 16 PCs —
PPM011997 PSS007857|
African Ancestry|
2,448 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.0966 [0.0571, 0.1359] sex, age, birth date, deprivation index, 16 PCs —
PPM011998 PSS008961|
African Ancestry|
3,849 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hand grip strength (mean of both) — — Partial Correlation (partial-r): 0.0798 [0.0482, 0.1112] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008293 — — 6,223 individuals — South Asian India (South Asia) UKB —
PSS008741 — — 6,598 individuals — European Italy (South Europe) UKB —
PSS009413 — — 19,855 individuals — European UK (+ Ireland) UKB —
PSS008070 — — 1,799 individuals — East Asian China (East Asia) UKB —
PSS007857 — — 2,448 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009187 — — 4,105 individuals — European Poland (NE Europe) UKB —
PSS008961 — — 3,849 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008515 — — 1,168 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —