Polygenic Score (PGS) ID: PGS002199

Predicted Trait
Reported Trait Ventricular rate
Mapped Trait(s) ventricular rate measurement (EFO_0007928)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_ventricular_rate
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 705,680
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012439 PSS009469|
European Ancestry|
1,711 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): 0.1563 [0.1094, 0.2024] sex, age, birth date, deprivation index, 16 PCs —
PPM012440 PSS009243|
European Ancestry|
329 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): 0.1975 [0.0879, 0.3024] sex, age, birth date, deprivation index, 16 PCs —
PPM012441 PSS008797|
European Ancestry|
490 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): 0.1785 [0.0894, 0.2646] sex, age, birth date, deprivation index, 16 PCs —
PPM012442 PSS008571|
Greater Middle Eastern Ancestry|
50 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): -0.2917 [-0.59, 0.0766] sex, age, birth date, deprivation index, 16 PCs —
PPM012443 PSS008349|
South Asian Ancestry|
307 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): 0.066 [-0.0501, 0.1804] sex, age, birth date, deprivation index, 16 PCs —
PPM012445 PSS007913|
African Ancestry|
78 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): 0.0201 [-0.2394, 0.277] sex, age, birth date, deprivation index, 16 PCs —
PPM012446 PSS009017|
African Ancestry|
140 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): -0.0905 [-0.2655, 0.0902] sex, age, birth date, deprivation index, 16 PCs —
PPM012444 PSS008126|
East Asian Ancestry|
137 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ventricular rate — — Partial Correlation (partial-r): 0.0478 [-0.1349, 0.2274] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008349 — — 307 individuals — South Asian India (South Asia) UKB —
PSS007913 — — 78 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008797 — — 490 individuals — European Italy (South Europe) UKB —
PSS009017 — — 140 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009243 — — 329 individuals — European Poland (NE Europe) UKB —
PSS008571 — — 50 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009469 — — 1,711 individuals — European UK (+ Ireland) UKB —
PSS008126 — — 137 individuals — East Asian China (East Asia) UKB —