Polygenic Score (PGS) ID: PGS002224

Predicted Trait
Reported Trait Sitting height
Mapped Trait(s) sitting height measurement (EFO_0011011)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_sitting_height
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 910,252
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012641 PSS008592|
Greater Middle Eastern Ancestry|
1,175 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.3911 [0.3411, 0.4389] sex, age, birth date, deprivation index, 16 PCs —
PPM012638 PSS009490|
European Ancestry|
19,908 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.4963 [0.4858, 0.5067] sex, age, birth date, deprivation index, 16 PCs —
PPM012639 PSS009264|
European Ancestry|
4,122 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.4829 [0.4591, 0.506] sex, age, birth date, deprivation index, 16 PCs —
PPM012640 PSS008818|
European Ancestry|
6,623 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.4602 [0.441, 0.479] sex, age, birth date, deprivation index, 16 PCs —
PPM012642 PSS008370|
South Asian Ancestry|
6,123 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.3797 [0.358, 0.4009] sex, age, birth date, deprivation index, 16 PCs —
PPM012643 PSS008146|
East Asian Ancestry|
1,800 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.3372 [0.2954, 0.3778] sex, age, birth date, deprivation index, 16 PCs —
PPM012645 PSS009038|
African Ancestry|
3,857 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.1914 [0.1607, 0.2217] sex, age, birth date, deprivation index, 16 PCs —
PPM012644 PSS007934|
African Ancestry|
2,443 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sitting height — — Partial Correlation (partial-r): 0.2361 [0.1982, 0.2734] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009038 — — 3,857 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009264 — — 4,122 individuals — European Poland (NE Europe) UKB —
PSS008592 — — 1,175 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008818 — — 6,623 individuals — European Italy (South Europe) UKB —
PSS008370 — — 6,123 individuals — South Asian India (South Asia) UKB —
PSS009490 — — 19,908 individuals — European UK (+ Ireland) UKB —
PSS008146 — — 1,800 individuals — East Asian China (East Asia) UKB —
PSS007934 — — 2,443 individuals — African American or Afro-Caribbean Carribean UKB —