Predicted Trait | |
Reported Trait | Neuroticism |
Mapped Trait(s) | neuroticism measurement (EFO_0007660) |
Score Construction | |
PGS Name | mental_NEUROTICISM.BOLT-LMM |
Development Method | |
Name | BOLT-LMM |
Parameters | NR |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 1,109,311 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000332 |
Citation (link to publication) | Weissbrod O et al. Nat Genet (2022) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | European: 100% 274,316 individuals (100%) |
PGS Evaluation | African: 25% East Asian: 25% European: 25% South Asian: 25% 4 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
— | 274,316 individuals | European | UKB |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM013107 | PSS009811| African Ancestry| 4,454 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Neuroticism | — | — | Incremental R2 (full model vs. covariates alone): 0.0025 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
PPM013156 | PSS009812| East Asian Ancestry| 603 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Neuroticism | — | — | Incremental R2 (full model vs. covariates alone): 0.0099 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
PPM013205 | PSS009813| European Ancestry| 34,276 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Neuroticism | — | — | Incremental R2 (full model vs. covariates alone): 0.0309 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
PPM013254 | PSS009814| South Asian Ancestry| 4,984 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Neuroticism | — | — | Incremental R2 (full model vs. covariates alone): 0.0238 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS009812 | — | — | 603 individuals | — | East Asian | — | UKB | — |
PSS009813 | — | — | 34,276 individuals | — | European | Non-British European | UKB | — |
PSS009814 | — | — | 4,984 individuals | — | South Asian | — | UKB | — |
PSS009811 | — | — | 4,454 individuals | — | African unspecified | — | UKB | — |