Polygenic Score (PGS) ID: PGS002448

Predicted Trait
Reported Trait Forced vital capacity
Mapped Trait(s) vital capacity (EFO_0004312)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name lung_FVCzSMOKE.P+T.0.001
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 0.001
Variants
Original Genome Build GRCh37
Number of Variants 29,603
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
274,172 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 274,172 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013576 PSS009751|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0006 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013674 PSS009753|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0381 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013723 PSS009754|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0045 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013625 PSS009752|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0052 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009751 — — 4,243 individuals — African unspecified — UKB —
PSS009752 — — 679 individuals — East Asian — UKB —
PSS009753 — — 34,753 individuals — European Non-British European UKB —
PSS009754 — — 5,538 individuals — South Asian — UKB —