Trait: vital capacity

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004312
Description The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Trait category
Other measurement
Synonyms 2 synonyms
  • FVC
  • forced vital capacity
Mapped terms 4 mapped terms
  • MeSH:D014797
  • MedDRA:10047579
  • NCIt:C111361
  • SNOMEDCT:268379003

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
JSONXMLCSVTXTMS-Excel
Loading, please wait
Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS001237
(GBE_INI3062)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Lung function (FVC)vital capacity20,921
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001237/ScoringFiles/PGS001237.txt.gz
PGS001922
(portability-PLR_FVC)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Forced vital capacity (FVC), Best measurevital capacity85,349
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001922/ScoringFiles/PGS001922.txt.gz
PGS002138
(portability-ldpred2_FVC)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Forced vital capacity (FVC), Best measurevital capacity940,300
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002138/ScoringFiles/PGS002138.txt.gz
PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity1,109,311
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002327/ScoringFiles/PGS002327.txt.gz
PGS002399
(lung_FVCzSMOKE.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity9,469
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002399/ScoringFiles/PGS002399.txt.gz
PGS002448
(lung_FVCzSMOKE.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity29,603
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002448/ScoringFiles/PGS002448.txt.gz
PGS002497
(lung_FVCzSMOKE.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity134,519
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002497/ScoringFiles/PGS002497.txt.gz
PGS002546
(lung_FVCzSMOKE.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity2,327
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002546/ScoringFiles/PGS002546.txt.gz
PGS002595
(lung_FVCzSMOKE.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity1,235
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002595/ScoringFiles/PGS002595.txt.gz
PGS002644
(lung_FVCzSMOKE.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity592,696
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002644/ScoringFiles/PGS002644.txt.gz
PGS002693
(lung_FVCzSMOKE.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced vital capacityvital capacity986,815
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002693/ScoringFiles/PGS002693.txt.gz
PGS004432
(X3062.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
Forced vital capacity (FVC)vital capacity1,059,939
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004432/ScoringFiles/PGS004432.txt.gz
PGS004436
(X20151.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
Forced vital capacity (FVC), Best measurevital capacity1,059,939
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004436/ScoringFiles/PGS004436.txt.gz
Showing 1 to 13 of 13 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM008694PGS001237
(GBE_INI3062)
PSS007081|
African Ancestry|
5,865 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC——R²: 0.38605 [0.3675, 0.40459]
Incremental R2 (full-covars): -0.00854
PGS R2 (no covariates): 0.00449 [0.00125, 0.00774]		age, sex, UKB array type, Genotype PCs—
PPM008695PGS001237
(GBE_INI3062)
PSS007082|
East Asian Ancestry|
1,590 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC——R²: 0.48915 [0.45529, 0.52301]
Incremental R2 (full-covars): 0.0239
PGS R2 (no covariates): 0.03634 [0.01893, 0.05375]		age, sex, UKB array type, Genotype PCs—
PPM008696PGS001237
(GBE_INI3062)
PSS007083|
European Ancestry|
22,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC——R²: 0.53532 [0.52687, 0.54376]
Incremental R2 (full-covars): 0.04669
PGS R2 (no covariates): 0.04902 [0.04379, 0.05425]		age, sex, UKB array type, Genotype PCs—
PPM008697PGS001237
(GBE_INI3062)
PSS007084|
South Asian Ancestry|
7,147 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC——R²: 0.42603 [0.40944, 0.44262]
Incremental R2 (full-covars): 0.00884
PGS R2 (no covariates): 0.02153 [0.01517, 0.02789]		age, sex, UKB array type, Genotype PCs—
PPM008698PGS001237
(GBE_INI3062)
PSS007085|
European Ancestry|
62,090 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC——R²: 0.51644 [0.5112, 0.52169]
Incremental R2 (full-covars): 0.04662
PGS R2 (no covariates): 0.04936 [0.04617, 0.05255]		age, sex, UKB array type, Genotype PCs—
PPM010255PGS001922
(portability-PLR_FVC)
PSS009370|
European Ancestry|
15,118 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.3635 [0.3496, 0.3773]sex, age, birth date, deprivation index, 16 PCs—
PPM010256PGS001922
(portability-PLR_FVC)
PSS009144|
European Ancestry|
2,907 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.346 [0.3135, 0.3777]sex, age, birth date, deprivation index, 16 PCs—
PPM010257PGS001922
(portability-PLR_FVC)
PSS008698|
European Ancestry|
4,520 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.3258 [0.2995, 0.3517]sex, age, birth date, deprivation index, 16 PCs—
PPM010258PGS001922
(portability-PLR_FVC)
PSS008472|
Greater Middle Eastern Ancestry|
163 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.307 [0.1505, 0.4486]sex, age, birth date, deprivation index, 16 PCs—
PPM011955PGS002138
(portability-ldpred2_FVC)
PSS009370|
European Ancestry|
15,118 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.3604 [0.3464, 0.3742]sex, age, birth date, deprivation index, 16 PCs—
PPM011956PGS002138
(portability-ldpred2_FVC)
PSS009144|
European Ancestry|
2,907 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.3369 [0.3042, 0.3689]sex, age, birth date, deprivation index, 16 PCs—
PPM011957PGS002138
(portability-ldpred2_FVC)
PSS008698|
European Ancestry|
4,520 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.3329 [0.3066, 0.3586]sex, age, birth date, deprivation index, 16 PCs—
PPM011958PGS002138
(portability-ldpred2_FVC)
PSS008472|
Greater Middle Eastern Ancestry|
163 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure——Partial Correlation (partial-r): 0.3085 [0.1521, 0.4499]sex, age, birth date, deprivation index, 16 PCs—
PPM013092PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity——Incremental R2 (full model vs. covariates alone): 0.0293age, sex, age*sex, assessment center, genotyping array, 10 PCs—
PPM013141PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity——Incremental R2 (full model vs. covariates alone): 0.0397age, sex, age*sex, assessment center, genotyping array, 10 PCs—
Showing 1 to 15 of 47 rows
152550All
rows per page

Evaluated Samples

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS007081——5,865 individuals—African unspecified—UKB—
PSS007082——1,590 individuals—East Asian—UKB—
PSS007083——22,831 individuals—Europeannon-white British ancestryUKB—
PSS007084——7,147 individuals—South Asian—UKB—
PSS007085——62,090 individuals—Europeanwhite British ancestryUKBTesting cohort (heldout set)
PSS008472——163 individuals—Greater Middle Eastern (Middle Eastern, North African or Persian)Iran (Middle East)UKB—
PSS008698——4,520 individuals—EuropeanItaly (South Europe)UKB—
PSS009144——2,907 individuals—EuropeanPoland (NE Europe)UKB—
PSS009370——15,118 individuals—EuropeanUK (+ Ireland)UKB—
PSS009751——4,243 individuals—African unspecified—UKB—
PSS009752——679 individuals—East Asian—UKB—
PSS009753——34,753 individuals—EuropeanNon-British EuropeanUKB—
PSS009754——5,538 individuals—South Asian—UKB—
PSS011364——56,192 individuals—European—UKB—
Showing 1 to 14 of 14 rows