Polygenic Score (PGS) ID: PGS002693

Predicted Trait
Reported Trait Forced vital capacity
Mapped Trait(s) vital capacity (EFO_0004312)
Released in PGS Catalog: June 9, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name lung_FVCzSMOKE.SBayesR
Development Method
Name SBayesR
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 986,815
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
274,172 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 274,172 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014556 PSS009751|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0276 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014605 PSS009752|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0474 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014654 PSS009753|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0952 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014703 PSS009754|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Forced Vital Capacity — — Incremental R2 (full model vs. covariates alone): 0.0658 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009751 — — 4,243 individuals — African unspecified — UKB —
PSS009752 — — 679 individuals — East Asian — UKB —
PSS009753 — — 34,753 individuals — European Non-British European UKB —
PSS009754 — — 5,538 individuals — South Asian — UKB —