Polygenic Score (PGS) ID: PGS002626

Predicted Trait
Reported Trait Number of children ever born
Mapped Trait(s) number of children ever born measurement (EFO_0009102)
Additional Trait Information #Children
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name repro_NumberChildrenEverBorn_Pooled.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 208,715
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
335,600 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 335,600 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014391 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0011 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014440 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0082 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014489 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.003 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014342 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009679 — — 6,193 individuals — African unspecified — UKB —
PSS009680 — — 909 individuals — East Asian — UKB —
PSS009681 — — 43,069 individuals — European Non-British European UKB —
PSS009682 — — 7,846 individuals — South Asian — UKB —