Polygenic Score (PGS) ID: PGS002626

Predicted Trait
Reported Trait Number of children ever born
Mapped Trait(s) number of children ever born measurement (EFO_0009102)
Additional Trait Information #Children
Released in PGS Catalog: June 9, 2022
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name repro_NumberChildrenEverBorn_Pooled.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 208,715
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
335,600 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
335,600 individualsEuropeanUKB
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM014342PSS009679|
African Ancestry|
6,193 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Number of children ever bornIncremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0005age, sex, age*sex, assessment center, genotyping array, 10 PCsSee repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup... /polypred_results for combination weightsShow more
PPM014391PSS009680|
East Asian Ancestry|
909 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Number of children ever bornIncremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0011age, sex, age*sex, assessment center, genotyping array, 10 PCsSee repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup... /polypred_results for combination weightsShow more
PPM014440PSS009681|
European Ancestry|
43,069 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Number of children ever bornIncremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0082age, sex, age*sex, assessment center, genotyping array, 10 PCsSee repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup... /polypred_results for combination weightsShow more
PPM014489PSS009682|
South Asian Ancestry|
7,846 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Number of children ever bornIncremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.003age, sex, age*sex, assessment center, genotyping array, 10 PCsSee repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup... /polypred_results for combination weightsShow more
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0096796,193 individualsAfrican unspecifiedUKB
PSS009680909 individualsEast AsianUKB
PSS00968143,069 individualsEuropeanNon-British EuropeanUKB
PSS0096827,846 individualsSouth AsianUKB
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