Trait: number of children ever born measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009102
Description A measurement of the number of children born
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002309
(repro_NumberChildrenEverBorn_Pooled.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002309/ScoringFiles/PGS002309.txt.gz
PGS002381
(repro_NumberChildrenEverBorn_Pooled.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 1,639
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002381/ScoringFiles/PGS002381.txt.gz
PGS002430
(repro_NumberChildrenEverBorn_Pooled.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 11,512
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002430/ScoringFiles/PGS002430.txt.gz
PGS002479
(repro_NumberChildrenEverBorn_Pooled.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 89,453
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002479/ScoringFiles/PGS002479.txt.gz
PGS002528
(repro_NumberChildrenEverBorn_Pooled.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 66
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002528/ScoringFiles/PGS002528.txt.gz
PGS002577
(repro_NumberChildrenEverBorn_Pooled.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 21
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002577/ScoringFiles/PGS002577.txt.gz
PGS002626
(repro_NumberChildrenEverBorn_Pooled.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 208,715
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002626/ScoringFiles/PGS002626.txt.gz
PGS002675
(repro_NumberChildrenEverBorn_Pooled.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 981,889
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002675/ScoringFiles/PGS002675.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013123 PGS002309
(repro_NumberChildrenEverBorn_Pooled.BOLT-LMM)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0011 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013172 PGS002309
(repro_NumberChildrenEverBorn_Pooled.BOLT-LMM)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0082 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013221 PGS002309
(repro_NumberChildrenEverBorn_Pooled.BOLT-LMM)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0032 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013074 PGS002309
(repro_NumberChildrenEverBorn_Pooled.BOLT-LMM)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013362 PGS002381
(repro_NumberChildrenEverBorn_Pooled.P+T.0.0001)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013411 PGS002381
(repro_NumberChildrenEverBorn_Pooled.P+T.0.0001)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0013 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013460 PGS002381
(repro_NumberChildrenEverBorn_Pooled.P+T.0.0001)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013509 PGS002381
(repro_NumberChildrenEverBorn_Pooled.P+T.0.0001)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013558 PGS002430
(repro_NumberChildrenEverBorn_Pooled.P+T.0.001)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: #Children — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013607 PGS002430
(repro_NumberChildrenEverBorn_Pooled.P+T.0.001)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: #Children — — Incremental R2 (full model vs. covariates alone): 0.0006 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013656 PGS002430
(repro_NumberChildrenEverBorn_Pooled.P+T.0.001)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: #Children — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013705 PGS002430
(repro_NumberChildrenEverBorn_Pooled.P+T.0.001)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: #Children — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013754 PGS002479
(repro_NumberChildrenEverBorn_Pooled.P+T.0.01)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0009 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013852 PGS002479
(repro_NumberChildrenEverBorn_Pooled.P+T.0.01)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013901 PGS002479
(repro_NumberChildrenEverBorn_Pooled.P+T.0.01)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013803 PGS002479
(repro_NumberChildrenEverBorn_Pooled.P+T.0.01)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0042 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013950 PGS002528
(repro_NumberChildrenEverBorn_Pooled.P+T.1e-06)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013999 PGS002528
(repro_NumberChildrenEverBorn_Pooled.P+T.1e-06)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0047 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014048 PGS002528
(repro_NumberChildrenEverBorn_Pooled.P+T.1e-06)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014097 PGS002528
(repro_NumberChildrenEverBorn_Pooled.P+T.1e-06)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014146 PGS002577
(repro_NumberChildrenEverBorn_Pooled.P+T.5e-08)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0006 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014195 PGS002577
(repro_NumberChildrenEverBorn_Pooled.P+T.5e-08)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0023 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014244 PGS002577
(repro_NumberChildrenEverBorn_Pooled.P+T.5e-08)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014293 PGS002577
(repro_NumberChildrenEverBorn_Pooled.P+T.5e-08)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014391 PGS002626
(repro_NumberChildrenEverBorn_Pooled.PolyFun-pred)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0011 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014440 PGS002626
(repro_NumberChildrenEverBorn_Pooled.PolyFun-pred)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0082 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014489 PGS002626
(repro_NumberChildrenEverBorn_Pooled.PolyFun-pred)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.003 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014342 PGS002626
(repro_NumberChildrenEverBorn_Pooled.PolyFun-pred)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014636 PGS002675
(repro_NumberChildrenEverBorn_Pooled.SBayesR)
 PSS009681|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0075 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014538 PGS002675
(repro_NumberChildrenEverBorn_Pooled.SBayesR)
 PSS009679|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0011 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014587 PGS002675
(repro_NumberChildrenEverBorn_Pooled.SBayesR)
 PSS009680|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014685 PGS002675
(repro_NumberChildrenEverBorn_Pooled.SBayesR)
 PSS009682|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Number of children ever born — — Incremental R2 (full model vs. covariates alone): 0.0032 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009679 — — 6,193 individuals — African unspecified — UKB —
PSS009680 — — 909 individuals — East Asian — UKB —
PSS009681 — — 43,069 individuals — European Non-British European UKB —
PSS009682 — — 7,846 individuals — South Asian — UKB —