Polygenic Score (PGS) ID: PGS002659

Predicted Trait
Reported Trait Neuroticism
Mapped Trait(s) neuroticism measurement (EFO_0007660)
Released in PGS Catalog: June 9, 2022
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name mental_NEUROTICISM.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 546,323
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
274,316 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 274,316 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014375 PSS009811|
African Ancestry|
4,454 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Neuroticism — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0024 age, sex, age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014424 PSS009812|
East Asian Ancestry|
603 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Neuroticism — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0099 age, sex, age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014473 PSS009813|
European Ancestry|
34,276 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Neuroticism — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0296 age, sex, age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014522 PSS009814|
South Asian Ancestry|
4,984 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Neuroticism — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0145 age, sex, age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009812 — — 603 individuals — East Asian — UKB —
PSS009813 — — 34,276 individuals — European Non-British European UKB —
PSS009814 — — 4,984 individuals — South Asian — UKB —
PSS009811 — — 4,454 individuals — African unspecified — UKB —