Polygenic Score (PGS) ID: PGS002734

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: July 21, 2022
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Score Details

Score Construction
PGS Name GRS_SBP_362
Development Method
Name Genome-wide significant variants
Parameters P<1E-06
Variants
Original Genome Build NR
Number of Variants 362
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000343
Citation (link to publication) Marques-Vidal P et al. J Hypertens (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
757,601 individuals (100%)
PGS Evaluation
Not Reported: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006624
Europe PMC: 30224653
 757,601 individuals European MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014825 PSS009904|
Ancestry Not Reported|
2,944 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels untreated for hypertension — — Correlation: 0.062 [0.026, 0.098] — —
PPM014826 PSS009905|
Ancestry Not Reported|
2,541 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels untreated for hypertension — — Correlation: 0.783 [0.488, 1.079] — —
PPM014827 PSS009906|
Ancestry Not Reported|
1,920 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels untreated for hypertension — — Correlation: 0.05 [0.003, 0.096] — —
PPM014828 PSS009903|
Ancestry Not Reported|
4,333 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels treated for hypertension — — Correlation: 0.054 [-0.006, 0.113] — —
PPM014829 PSS009904|
Ancestry Not Reported|
2,944 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels treated for hypertension — — Correlation: 0.045 [-0.011, 0.102] — —
PPM014830 PSS009905|
Ancestry Not Reported|
2,541 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels treated for hypertension — — Correlation: 0.05 [-0.012, 0.111] — —
PPM014831 PSS009906|
Ancestry Not Reported|
1,920 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels treated for hypertension — — Correlation: 0.066 [-0.001, 0.133] — —
PPM014824 PSS009903|
Ancestry Not Reported|
4,333 individuals
 PGP000343 |
Marques-Vidal P et al. J Hypertens (2022)
 Reported Trait: Systolic blood pressure levels untreated for hypertension — — Correlation: 0.086 [0.058, 0.115] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009903 — — 4,333 individuals,
46.0 % Male samples
 Mean = 52.0 years Not reported — CoLaus CoLaus|PsyCoLaus
PSS009904 — — 2,944 individuals,
44.0 % Male samples
 Mean = 56.0 years Not reported — CoLaus CoLaus|PsyCoLaus
PSS009905 — — 2,541 individuals,
42.0 % Male samples
 Mean = 61.0 years Not reported — CoLaus CoLaus|PsyCoLaus
PSS009906 — — 1,920 individuals,
41.0 % Male samples
 Mean = 63.0 years Not reported — CoLaus CoLaus|PsyCoLaus