Polygenic Score (PGS) ID: PGS002744

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal cancer (MONDO_0005575)
Released in PGS Catalog: Aug. 3, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS115_EUR_EAS
Development Method
Name Genome-wide significant SNPs
Parameters r2<0.1, MAF>1%
Variants
Original Genome Build hg19
Number of Variants 115
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000354
Citation (link to publication) Ping J et al. Int J Cancer (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 61.9%
East Asian: 36.5%
African: 1.3%
Additional Diverse Ancestries: 0.2%
495,045 individuals (100%)
Score Development/Training
East Asian: 100%
235,188 individuals (100%)
PGS Evaluation
East Asian: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
JSONXMLCSVTXTMS-Excel
Loading, please wait
Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Europe PMC: 27005424
[
  • 13,656 cases
  • , 21,667 controls
]
EuropeanNR
GWAS Catalog: GCST000168
Europe PMC: 18372901
1,983 individualsEuropean
(U.K.)		NR
GWAS Catalog: GCST000270
Europe PMC: 19011631
3,831 individualsEuropeanCOGS, CoRGI
GWAS Catalog: GCST000843
Europe PMC: 20972440
7,962 individualsEuropean11 cohorts
  • B58C
  • ,COGS
  • ,COIN
  • ,COIN-B
  • ,CoRGI
  • ,FCCPS
  • ,NSCCG
  • ,SEARCH
  • ,SOCCS
  • ,UKBS
  • ,VICTOR
GWAS Catalog: GCST000843
Europe PMC: 20972440
30,420 individualsEuropean11 cohorts
  • B58C
  • ,COGS
  • ,COIN
  • ,COIN-B
  • ,CoRGI
  • ,FCCPS
  • ,NSCCG
  • ,SEARCH
  • ,SOCCS
  • ,UKBS
  • ,VICTOR
GWAS Catalog: GCST001544
Europe PMC: 22634755
17,780 individualsEuropeanCOGS, CoRGI, NSCCG, SOCCS, VICTOR
GWAS Catalog: GCST002411
Europe PMC: 24737748
13,443 individualsEuropeanNR
GWAS Catalog: GCST002454
Europe PMC: 24836286
8,270 individualsEast AsianAichi_Con, Guangzhou, KCPS, Shanghai
GWAS Catalog: GCST002528
Europe PMC: 25023989
983 individualsOtherCCFR, MECC
GWAS Catalog: GCST002528
Europe PMC: 25023989
2,976 individualsEuropeanCCFR, MECC
GWAS Catalog: GCST002561
Europe PMC: 25105248
6,596 individualsAfrican American or Afro-Caribbean11 cohorts
  • CCFR
  • ,FCCS
  • ,Hawaiian_Colo2&3
  • ,JPHC
  • ,MDACCS
  • ,MEC
  • ,NCCS
  • ,PLCO
  • ,SCCS
  • ,UNC-Rectal
  • ,UNCCanCORS
GWAS Catalog: GCST002561
Europe PMC: 25105248
6,424 individualsEast Asian11 cohorts
  • CCFR
  • ,FCCS
  • ,Hawaiian_Colo2&3
  • ,JPHC
  • ,MDACCS
  • ,MEC
  • ,NCCS
  • ,PLCO
  • ,SCCS
  • ,UNC-Rectal
  • ,UNCCanCORS
GWAS Catalog: GCST003494
Europe PMC: 27145994
2,329 individualsEast AsianNJ_Study
GWAS Catalog: GCST003799
Europe PMC: 26965516
21,096 individualsEast AsianBBJ, Guangzhou, KCPS, Shanghai
GWAS Catalog: GCST006131
Europe PMC: 29917119
67,812 individualsEuropeanNR
Showing 1 to 15 of 19 rows
1525All
rows per page
Score Development/Training
JSONXMLCSVTXTMS-Excel
Loading, please wait
Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—
[
  • 22,702 cases
  • , 212,486 controls
]
East Asian
(Chinese, Japanese, Korean)		7 cohorts
  • Aichi
  • ,BBJ
  • ,Guangzhou
  • ,HCES-CRC
  • ,KCPS
  • ,Korea-NCC
  • ,Korea-Seoul
————Shanghai Studies
Showing 1 to 1 of 1 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM014908PSS009924|
East Asian Ancestry|
1,454 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancerOR: 1.68 [1.5, 1.89]AUROC: 0.64 [0.61, 0.67]———
PPM014911PSS009923|
East Asian Ancestry|
1,736 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancerOR: 1.5 [1.36, 1.66]AUROC: 0.61 [0.58, 0.64]———
Showing 1 to 2 of 2 rows

Evaluated Samples

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS009923——
[
  • 868 cases
  • , 868 controls
]
—East Asian
(Chinese)		—NR—
PSS009924——
[
  • 622 cases
  • , 832 controls
]
—East Asian
(Korean)		—NR—
Showing 1 to 2 of 2 rows