PGS Publication: PGP000354

Publication Information (EuropePMC)
Title Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians.
PubMed ID 35765848(Europe PMC)
doi 10.1002/ijc.34194
Publication Date June 29, 2022
Journal Int J Cancer
Author(s) Ping J, Yang Y, Wen W, Kweon SS, Matsuda K, Jia WH, Shin A, Gao YT, Matsuo K, Kim J, Kim DH, Jee SH, Cai Q, Chen Z, Tao R, Shin MH, Tanikawa C, Pan ZZ, Oh JH, Oze I, Ahn YO, Jung KJ, Ren Z, Shu XO, Long J, Zheng W.
Released in PGS Catalog: Aug. 3, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002742
(PRS115_EAS)
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Colorectal cancer colorectal cancer 115
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002742/ScoringFiles/PGS002742.txt.gz
PGS002743
(PRS115_EUR)
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Colorectal cancer colorectal cancer 115
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002743/ScoringFiles/PGS002743.txt.gz
PGS002744
(PRS115_EUR_EAS)
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Colorectal cancer colorectal cancer 115
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002744/ScoringFiles/PGS002744.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014906 PGS002742
(PRS115_EAS)
 PSS009924|
East Asian Ancestry|
1,454 individuals
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Reported Trait: Colorectal cancer OR: 1.63 [1.46, 1.83] AUROC: 0.63 [0.6, 0.66] — — —
PPM014907 PGS002743
(PRS115_EUR)
 PSS009924|
East Asian Ancestry|
1,454 individuals
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Reported Trait: Colorectal cancer OR: 1.44 [1.29, 1.6] AUROC: 0.6 [0.57, 0.63] — — —
PPM014908 PGS002744
(PRS115_EUR_EAS)
 PSS009924|
East Asian Ancestry|
1,454 individuals
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Reported Trait: Colorectal cancer OR: 1.68 [1.5, 1.89] AUROC: 0.64 [0.61, 0.67] — — —
PPM014909 PGS002742
(PRS115_EAS)
 PSS009923|
East Asian Ancestry|
1,736 individuals
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Reported Trait: Colorectal cancer OR: 1.51 [1.37, 1.67] AUROC: 0.61 [0.59, 0.64] — — —
PPM014910 PGS002743
(PRS115_EUR)
 PSS009923|
East Asian Ancestry|
1,736 individuals
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Reported Trait: Colorectal cancer OR: 1.39 [1.26, 1.53] AUROC: 0.59 [0.56, 0.61] — — —
PPM014911 PGS002744
(PRS115_EUR_EAS)
 PSS009923|
East Asian Ancestry|
1,736 individuals
 PGP000354 |
Ping J et al. Int J Cancer (2022)
 Reported Trait: Colorectal cancer OR: 1.5 [1.36, 1.66] AUROC: 0.61 [0.58, 0.64] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009924 — —
[
  • 622 cases
  • , 832 controls
]
 — East Asian
(Korean)		 — NR —
PSS009923 — —
[
  • 868 cases
  • , 868 controls
]
 — East Asian
(Chinese)		 — NR —