Polygenic Score (PGS) ID: PGS002786

Predicted Trait
Reported Trait Bipolar disorder
Mapped Trait(s) bipolar disorder (MONDO_0004985)
Released in PGS Catalog: Sept. 29, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name BD_SDPR
Development Method
Name SDPR
Parameters used hapmap3 SNPs from genotype in 1000G as the reference panel, MAF>0.05
Variants
Original Genome Build hg19
Number of Variants 948,996
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000370
Citation (link to publication) Gui Y et al. Transl Psychiatry (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
41,653 individuals (100%)
PGS Evaluation
European: 100%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 29906448
[
  • 20,129 cases
  • , 21,524 controls
]
 European PGC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015111 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.00032 age, PCs1-3 —
PPM015112 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 6e-05 age, PCs1-3 —
PPM015408 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Posterior corona radiata R — — partial R²: 0.00088 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015054 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 1e-05 age, PCs1-3 —
PPM015055 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 5e-05 age, PCs1-3 —
PPM015056 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00037 age, PCs1-3 —
PPM015057 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00045 age, PCs1-3 —
PPM015058 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 1.31e-06 age, PCs1-3 —
PPM015059 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 4e-05 age, PCs1-3 —
PPM015060 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00029 age, PCs1-3 —
PPM015061 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 9e-05 age, PCs1-3 —
PPM015062 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 4e-05 age, PCs1-3 —
PPM015063 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00015 age, PCs1-3 —
PPM015064 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 4e-05 age, PCs1-3 —
PPM015065 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00012 age, PCs1-3 —
PPM015066 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 2e-05 age, PCs1-3 —
PPM015067 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00028 age, PCs1-3 —
PPM015068 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 4e-05 age, PCs1-3 —
PPM015070 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 4e-05 age, PCs1-3 —
PPM015071 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00037 age, PCs1-3 —
PPM015072 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.0005 age, PCs1-3 —
PPM015073 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 3e-05 age, PCs1-3 —
PPM015074 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00014 age, PCs1-3 —
PPM015075 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 7e-05 age, PCs1-3 —
PPM015076 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00061 age, PCs1-3 —
PPM015077 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.00037 age, PCs1-3 —
PPM015078 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 0.00251 age, PCs1-3 —
PPM015079 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00023 age, PCs1-3 —
PPM015080 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 4e-05 age, PCs1-3 —
PPM015082 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 7.85e-06 age, PCs1-3 —
PPM015083 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00087 age, PCs1-3 —
PPM015084 PSS009953|
European Ancestry|
68,614 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 7e-05 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015085 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00119 age, PCs1-3 —
PPM015086 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00051 age, PCs1-3 —
PPM015087 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00027 age, PCs1-3 —
PPM015088 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00079 age, PCs1-3 —
PPM015089 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.0005 age, PCs1-3 —
PPM015090 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 7e-05 age, PCs1-3 —
PPM015091 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00077 age, PCs1-3 —
PPM015093 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00101 age, PCs1-3 —
PPM015094 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00034 age, PCs1-3 —
PPM015095 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00092 age, PCs1-3 —
PPM015096 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00196 age, PCs1-3 —
PPM015097 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00198 age, PCs1-3 —
PPM015098 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 1.76e-06 age, PCs1-3 —
PPM015099 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 7.78e-07 age, PCs1-3 —
PPM015100 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00022 age, PCs1-3 —
PPM015101 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00032 age, PCs1-3 —
PPM015102 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00067 age, PCs1-3 —
PPM015104 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00101 age, PCs1-3 —
PPM015105 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00186 age, PCs1-3 —
PPM015106 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 8.61e-07 age, PCs1-3 —
PPM015107 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 2e-05 age, PCs1-3 —
PPM015108 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 6e-05 age, PCs1-3 —
PPM015109 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 3e-05 age, PCs1-3 —
PPM015113 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 0.00135 age, PCs1-3 —
PPM015114 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00016 age, PCs1-3 —
PPM015409 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cingulum (cingulate gyrus) R — — partial R²: 0.00095 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015410 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Splenium of corpus callosum — — partial R²: 0.00099 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015411 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Sagittal stratum — — partial R²: 0.00095 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015412 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Uncinate fasciculus L — — partial R²: 0.0009 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015413 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Forceps major — — partial R²: 0.00092 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015415 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Inferior longitudinal fasciculus L — — partial R²: 0.00108 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015416 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Inferior longitudinal fasciculus R — — partial R²: 0.00128 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015417 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Uncinate fasciculus L — — partial R²: 0.00104 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015418 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Uncinate fasciculus R — — partial R²: 0.00089 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015419 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_83 — — partial R²: 0.00095 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015420 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_137 — — partial R²: 0.00119 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015421 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_176 — — partial R²: 0.00116 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015069 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 5e-05 age, PCs1-3 —
PPM015081 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00163 age, PCs1-3 —
PPM015092 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00017 age, PCs1-3 —
PPM015103 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.0005 age, PCs1-3 —
PPM015110 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00037 age, PCs1-3 —
PPM015115 PSS009951|
European Ancestry|
78,561 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 7e-05 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015414 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Inferior fronto-occipital fasciculus R — — partial R²: 0.00105 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009949 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,198 individuals,
0.0 % Male samples
 Mean = 9.89 years
Sd = 0.61 years		 European — ABCD —
PSS009950 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,524 individuals,
100.0 % Male samples
 Mean = 9.92 years
Sd = 0.62 years		 European — ABCD —
PSS009951 Fluid intelligence test — 78,561 individuals,
0.0 % Male samples
 Mean = 57.46 years
Sd = 8.08 years		 European — UKB —
PSS009952 imaging-derived phenotypes (IDPs) generated by an image-processing pipeline developed and ran on behalf of the UKB — 10,343 individuals,
0.0 % Male samples
 Mean = 63.13 years
Sd = 7.3 years		 European — UKB —
PSS009953 Fluid intelligence test — 68,614 individuals,
100.0 % Male samples
 Mean = 58.39 years
Sd = 8.36 years		 European — UKB —