Polygenic Score (PGS) ID: PGS002791

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Sept. 29, 2022
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Score Details

Score Construction
PGS Name PRS126_Pca
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 126
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000371
Citation (link to publication) Ruan X et al. Prostate (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 91.6%
Multi-ancestry (including European): 3.1%
  • European
  • Hispanic or Latin American
  • African
  • East Asian
  • Additional Diverse Ancestries
  • Not Reported
Not Reported: 2%
African: 1.8%
East Asian: 1.2%
Hispanic or Latin American: 0.4%
574,209 individuals (100%)
Score Development/Training
European: 96.2%
African: 2.8%
East Asian: 1.1%
109,323 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 20197460
[
  • 8,309 cases
  • , 9,286 controls
]
,
100.0 % Male samples
 European, Hispanic or Latin American, African unspecified, East Asian, Oceanian, Not reported
(White, Hispanic, Black, Japanese, Native Hawaiian, Unknown)		 NR
GWAS Catalog: GCST000488
Europe PMC: 19767753
 3,748 individuals European ProtecT, UKGPCS
GWAS Catalog: GCST000153
Europe PMC: 18264098
 23,226 individuals European ICR, IGD, deCODE
GWAS Catalog: GCST000489
Europe PMC: 19767754
 37,350 individuals European ICR, IGD, deCODE
GWAS Catalog: GCST011048
Europe PMC: 33398198
 177,526 individuals European NR
GWAS Catalog: GCST006083
Europe PMC: 29892016
 73,475 individuals European NR
GWAS Catalog: GCST000154
Europe PMC: 18264096
 2,329 individuals European PLCO
Europe PMC: 19767752
[
  • 5,504 cases
  • , 5,834 controls
]
,
100.0 % Male samples
 Not reported NR
GWAS Catalog: GCST000019
Europe PMC: 17401366
 4,517 individuals European ICR, IGD, deCODE
GWAS Catalog: GCST000128
Europe PMC: 18073375
 2,834 individuals European NR
Europe PMC: 18758462
[
  • 2,899 cases
  • , 1,722 controls
]
,
100.0 % Male samples
 European NR
Europe PMC: 26025378
[
  • 25,723 cases
  • , 26,274 controls
]
,
100.0 % Male samples
 European NR
GWAS Catalog: GCST000307
Europe PMC: 19117981
 2,834 individuals European NR
GWAS Catalog: GCST000050
Europe PMC: 17603485
 12,791 individuals European NR
Europe PMC: 19318570
[
  • 500 cases
  • , 500 controls
]
,
100.0 % Male samples
 European NR
GWAS Catalog: GCST001714
Europe PMC: 23065704
 22,548 individuals European NR
GWAS Catalog: GCST000017
Europe PMC: 17401363
 2,329 individuals European NR
—
[
  • 212 cases
  • , 1,313 controls
]
,
100.0 % Male samples
 European 37 cohorts
  • BCFR
  • ,BFBOCC
  • ,BRICOH
  • ,CBCS
  • ,CIMBA
  • ,CNIO
  • ,CONSIT
  • ,Chicago
  • ,DEMOKRITOS
  • ,DKFZ
  • ,EMBRACE
  • ,FCCC
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HUNBOCS
  • ,HVH
  • ,ICO
  • ,ILUH
  • ,IOVHBOCS
  • ,IPOBCS
  • ,MAYO
  • ,MSKCC
  • ,MUV
  • ,NCI
  • ,OCGN
  • ,OSU
  • ,OUH
  • ,PBCS
  • ,SWE-BRCA
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,kConFab
GWAS Catalog: GCST001942
Europe PMC: 23535732
 22,548 individuals European NR
GWAS Catalog: GCST002606
Europe PMC: 25217961
 2,080 individuals Hispanic or Latin American NR
GWAS Catalog: GCST002606
Europe PMC: 25217961
 6,954 individuals East Asian NR
GWAS Catalog: GCST002606
Europe PMC: 25217961
 10,463 individuals Sub-Saharan African, African American or Afro-Caribbean NR
GWAS Catalog: GCST002606
Europe PMC: 25217961
 67,543 individuals European NR
GWAS Catalog: GCST001147
Europe PMC: 21743057
 7,240 individuals European NR
GWAS Catalog: GCST000152
Europe PMC: 18264097
 3,748 individuals European ProtecT, UKGPCS
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 105,126 individuals European UKB — — — — —
— 3,008 individuals African American or Afro-Caribbean
(African American)		 AAPC — — — — —
— 1,189 individuals East Asian
(Chinese)		 NR — — — — ChinaPCa

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015448 PSS009957|
European Ancestry|
104,586 individuals
 PGP000371 |
Ruan X et al. Prostate (2022)
 Reported Trait: Prostate cancer risk — — Odds Ratio (OR, top vs average percentile): 3.79 [3.46, 4.16] disease diagnostic age or age at recruitment, subgroups and 10 principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009957 — — 104,586 individuals — European — UKB —