Publication Information (EuropePMC) | |
Title | Application of European-specific polygenic risk scores for predicting prostate cancer risk in different ancestry populations. |
PubMed ID | 35996327(Europe PMC) |
doi | 10.1002/pros.24431 |
Publication Date | Aug. 22, 2022 |
Journal | Prostate |
Author(s) | Ruan X, Huang D, Huang J, Xu D, Na R. |
Polygenic Score ID & Name
|
PGS Publication ID (PGP)
|
Reported Trait
|
Mapped Trait(s) (Ontology)
|
Number of Variants
|
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
|
---|---|---|---|---|---|---|
PGS002791 (PRS126_Pca) | PGP000371 | Ruan X et al. Prostate (2022) | Prostate cancer | prostate carcinoma | 126 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002791/ScoringFiles/PGS002791.txt.gz | |
PGS002792 (PRS67_Pca) | PGP000371 | Ruan X et al. Prostate (2022) | Prostate cancer | prostate carcinoma | 67 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002792/ScoringFiles/PGS002792.txt.gz | |
PGS002793 (PRS84_Pca) | PGP000371 | Ruan X et al. Prostate (2022) | Prostate cancer | prostate carcinoma | 82 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002793/ScoringFiles/PGS002793.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
|
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM015448 | PGS002791 (PRS126_Pca) | PSS009957| European Ancestry| 104,586 individuals | PGP000371 | Ruan X et al. Prostate (2022) | Reported Trait: Prostate cancer risk | — | — | Odds Ratio (OR, top vs average percentile): 3.79 [3.46, 4.16] | disease diagnostic age or age at recruitment, subgroups and 10 principal components | — |
PPM015449 | PGS002792 (PRS67_Pca) | PSS009955| African Ancestry| 3,008 individuals | PGP000371 | Ruan X et al. Prostate (2022) | Reported Trait: Prostate cancer risk | — | — | Odds Ratio (OR, top vs average percentile): 1.77 [1.22, 2.58] | disease diagnostic age or age at recruitment, subgroups and 10 principal components | — |
PPM015450 | PGS002793 (PRS84_Pca) | PSS009956| East Asian Ancestry| 1,190 individuals | PGP000371 | Ruan X et al. Prostate (2022) | Reported Trait: Prostate cancer risk | — | — | Odds Ratio (OR, top vs average percentile): 2.87 [1.29, 6.4] | disease diagnostic age or age at recruitment, subgroups and 10 principal components | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
PSS009955 | — | — | 3,008 individuals | — | African American or Afro-Caribbean (African American) | — | AAPC | — |
PSS009956 | — | — | 1,190 individuals | — | East Asian (Chinese) | — | NR | ChinaPCa |
PSS009957 | — | — | 104,586 individuals | — | European | — | UKB | — |