Polygenic Score (PGS) ID: PGS002795

Predicted Trait
Reported Trait Longevity (>90th survival percentile)
Mapped Trait(s) longevity (EFO_0004300)
Released in PGS Catalog: Oct. 19, 2022
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Score Details

Score Construction
PGS Name PRS_longetivity
Development Method
Name Genome-wide significant SNPs
Parameters r2>0.1, p<5E-08
Variants
Original Genome Build NR
Number of Variants 4
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000378
Citation (link to publication) Schoepf IC et al. Clin Infect Dis (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
36,745 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008598
Europe PMC: 31413261
 36,745 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015503 PSS009965|
European Ancestry|
836 individuals
 PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
 Reported Trait: Coronary artery disease — — Odds Ratio (OR, fifth vs. first quintile): 1.61 [0.89, 2.91] Clinical risk factors —
PPM015505 PSS009965|
European Ancestry|
836 individuals
 PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
 Reported Trait: Coronary artery disease — — Odds Ratio (OR, fifth vs. first quintile): 3.67 [2.0, 6.73] Clinical risk factors, PGS000018 Combined as metaPRS

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009965 CAD events were defined according to the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study and the MONICA Project of the World Health Organization, as reported elsewhere —
[
  • 269 cases
  • , 567 controls
]
 — European — SHCS —