| Publication Information (EuropePMC) | |
| Title | Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study. |
| PubMed ID | 34091660(Europe PMC) |
| doi | 10.1093/cid/ciab521 |
| Publication Date | Nov. 1, 2021 |
| Journal | Clin Infect Dis |
| Author(s) | Schoepf IC, Thorball CW, Ledergerber B, Engel T, Raffenberg M, Kootstra NA, Reiss P, Hasse B, Marzolini C, Thurnheer C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos R, Günthard HF, Fellay J, Tarr PE, Swiss HIV Cohort Study. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS002795 (PRS_longetivity) |
PGP000378 | Schoepf IC et al. Clin Infect Dis (2021) |
Longevity (>90th survival percentile) | longevity | 4 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002795/ScoringFiles/PGS002795.txt.gz |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000018 (metaGRS_CAD) |
PGP000007 | Inouye M et al. J Am Coll Cardiol (2018) |
Coronary artery disease | coronary artery disease | 1,745,179 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM015502 | PGS000018 (metaGRS_CAD) |
PSS009965| European Ancestry| 836 individuals |
PGP000378 | Schoepf IC et al. Clin Infect Dis (2021) |Ext. |
Reported Trait: Coronary artery disease | — | — | Odds Ratio (OR, fifth vs. first quintile): 3.17 [1.74, 5.79] | Clinical risk factors | — |
| PPM015503 | PGS002795 (PRS_longetivity) |
PSS009965| European Ancestry| 836 individuals |
PGP000378 | Schoepf IC et al. Clin Infect Dis (2021) |
Reported Trait: Coronary artery disease | — | — | Odds Ratio (OR, fifth vs. first quintile): 1.61 [0.89, 2.91] | Clinical risk factors | — |
| PPM015504 | PGS000018 (metaGRS_CAD) |
PSS009965| European Ancestry| 836 individuals |
PGP000378 | Schoepf IC et al. Clin Infect Dis (2021) |Ext. |
Reported Trait: Coronary artery disease | — | — | Odds Ratio (OR, fifth vs. first quintile): 3.67 [2.0, 6.73] | Clinical risk factors, PRS_longetivity | Combined as metaPRS |
| PPM015505 | PGS002795 (PRS_longetivity) |
PSS009965| European Ancestry| 836 individuals |
PGP000378 | Schoepf IC et al. Clin Infect Dis (2021) |
Reported Trait: Coronary artery disease | — | — | Odds Ratio (OR, fifth vs. first quintile): 3.67 [2.0, 6.73] | Clinical risk factors, PGS000018 | Combined as metaPRS |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009965 | CAD events were defined according to the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study and the MONICA Project of the World Health Organization, as reported elsewhere | — | [
|
— | European | — | SHCS | — |