PGS Publication: PGP000007

Publication Information (EuropePMC)
Title Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention.
PubMed ID 30309464(Europe PMC)
doi 10.1016/j.jacc.2018.07.079
Publication Date Oct. 1, 2018
Journal J Am Coll Cardiol
Author(s) Inouye M, Abraham G, Nelson CP, Wood AM, Sweeting MJ, Dudbridge F, Lai FY, Kaptoge S, Brozynska M, W... ang T, Ye S, Webb TR, Rutter MK, Tzoulaki I, Patel RS, Loos RJF, Keavney B, Hemingway H, Thompson J, Watkins H, Deloukas P, Di Angelantonio E, Butterworth AS, Danesh J, Samani NJ, UK Biobank CardioMetabolic Consortium CHD Working Group.Show more
Released in PGS Catalog: Oct. 14, 2019

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000018
(metaGRS_CAD)
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
Coronary artery diseasecoronary artery disease1,745,179
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
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External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000011
(GRS50)
PGP000004 |
Tada H et al. Eur Heart J (2015)
Coronary artery diseasecoronary artery disease50
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS000012
(GRS49K)
PGP000005 |
Abraham G et al. Eur Heart J (2016)
Coronary artery diseasecoronary artery disease49,310
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000012/ScoringFiles/PGS000012.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM000027PGS000018
(metaGRS_CAD)
PSS000018|
Multi-ancestry (including European)|
482,629 individuals
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
Reported Trait: Incident coronary artery diseaseHR: 1.706 [1.682, 1.73]AUROC: 0.79
C-index: 0.623 [0.615, 0.631]		AUPRC: 0.161sex, genetic PCs (1-10), genotyping arrayage-as-time-scale Cox regression
PPM000028PGS000012
(GRS49K)
PSS000018|
Multi-ancestry (including European)|
482,629 individuals
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
|Ext.		Reported Trait: Incident coronary artery diseaseHR: 1.524 [1.498, 1.551]——sex, genetic PCs (1-10), genotyping arrayUsed GRS46K (excludes A/T and C/G SNPs, with performance similar to GRS49K)
PPM000029PGS000011
(GRS50)
PSS000018|
Multi-ancestry (including European)|
482,629 individuals
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
|Ext.		Reported Trait: Incident coronary artery diseaseHR: 1.263 [1.247, 1.28]——sex, genetic PCs (1-10), genotyping array—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000018CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal cor... onary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75.Show more—
[
  • 22,242 cases
  • , 460,387 controls
]
,
45.6 % Male samples
—European, NR~95% European ancestry samples, <5% non-European ancestryUKB—
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