Polygenic Score (PGS) ID: PGS000011

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Oct. 14, 2019
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS50
Development Method
Name Genome-wide significant variants
Parameters Also includes the SNPs from GRS 27 (Mega et al.; PMID:25748612)
Variants
Original Genome Build NR
Number of Variants 50
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000004
Citation (link to publication) Tada H et al. Eur Heart J (2015)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 53.3%
  • European
  • South Asian
European: 40.3%
South Asian: 6.4%
365,042 individuals (100%)
PGS Evaluation
European: 61.5%
African: 15.4%
Hispanic or Latin American: 15.4%
Multi-ancestry (including European): 7.7%
  • European
  • Not Reported
13 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
JSONXMLCSVTXTMS-Excel
Loading, please wait
Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Europe PMC: 21966275
[
  • 11,202 cases
  • , 30,773 controls
]
European10 cohorts
  • ARIC
  • ,BHF-FHS
  • ,BLOODOMICS
  • ,CARDIA
  • ,CHS
  • ,FOS
  • ,KORA
  • ,MONICA
  • ,PROCARDIS
  • ,PennCATH
Europe PMC: 21966275
[
  • 4,394 cases
  • , 4,259 controls
]
South AsianLOLIPOP, PROMIS
Europe PMC: 23202125
[
  • 63,746 cases
  • , 130,681 controls
]
European, South Asian34 cohorts
  • ADVANCE
  • ,AMC-PAS
  • ,Angio-Lueb
  • ,CARDIOGENICS
  • ,COROGENE
  • ,DILGOM
  • ,Duke
  • ,EGCUT
  • ,EMIL
  • ,EPIC
  • ,FGENTCARD
  • ,FINCAVAS
  • ,FRISCII
  • ,GENRIC
  • ,GLACIER
  • ,GoDARTS
  • ,HPS
  • ,HSIEA
  • ,ITH
  • ,KORA
  • ,LOLIPOP
  • ,LURIC
  • ,METSIM
  • ,MORGAM
  • ,OHGS
  • ,PIVUS
  • ,PMB
  • ,POPGEN
  • ,PROCARDIS
  • ,PROMIS
  • ,SCARFSHEEP
  • ,STR
  • ,ULSAM
  • ,WTCCC
GWAS Catalog: GCST000338
Europe PMC: 19198612
2,520 individualsEuropeanNR
GWAS Catalog: GCST000998
Europe PMC: 2137899
86,995 individualsEuropeanNR
GWAS Catalog: GCST000999
Europe PMC: 21378988
14,790 individualsSouth Asian
(India, Pakistan)		NR
GWAS Catalog: GCST000999
Europe PMC: 21378988
15,682 individualsEuropeanNR
Showing 1 to 7 of 7 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM000016PSS000010|
European Ancestry|
23,595 individuals
PGP000004 |
Tada H et al. Eur Heart J (2015)
Reported Trait: Incident coronary heart diseaseHR: 1.23 [1.18, 1.28]——age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes—
PPM000029PSS000018|
Multi-ancestry (including European)|
482,629 individuals
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
|Ext.		Reported Trait: Incident coronary artery diseaseHR: 1.263 [1.247, 1.28]——sex, genetic PCs (1-10), genotyping array—
PPM000494PSS000283|
European Ancestry|
7,814 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		Reported Trait: Incident coronary artery disease——Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.75 [1.46, 2.1]age, sex, self reported education level, 5 genetic principal components—
PPM000495PSS000286|
European Ancestry|
21,222 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		Reported Trait: Incident coronary artery disease——Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.94 [1.58, 2.39]age, self reported education level, treatment (vitamin E vs aspirin), 5 genetic principal components—
PPM000496PSS000285|
European Ancestry|
22,389 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		Reported Trait: Incident coronary artery disease——Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.98 [1.76, 2.23]age, sex, self reported education level—
PPM000497PSS000284|
European Ancestry|
4,260 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		Reported Trait: Coronary artery calcification——Agatston score (mean, top 20% of GRS): 46.0 [9.0, 54.0]
Agatston score (mean, btttom 25% of GRS): 21.0 [18.0, 25.0]		——
PPM000589PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Incident coronary heart diseaseHR: 1.2 [1.15, 1.25]C-index: 0.698—sex, eMERGE site, first five ancestry-specific principal componentsAge-as-time-scale Cox regression
PPM000592PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Incident coronary heart diseaseHR: 1.05 [0.94, 1.17]C-index: 0.649—sex, eMERGE site, first five ancestry-specific principal componentsAge-as-time-scale Cox regression
PPM000595PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Incident coronary heart diseaseHR: 1.13 [0.93, 1.36]C-index: 0.654—sex, eMERGE site, first five ancestry-specific principal componentsAge-as-time-scale Cox regression
PPM000598PSS000333|
European Ancestry|
45,645 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Coronary heart disease (incident and prevalent)OR: 1.28 [1.25, 1.32]AUROC: 0.75—age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal c... omponentsShow more—
PPM000601PSS000331|
African Ancestry|
7,597 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Coronary heart disease (incident and prevalent)OR: 1.05 [0.98, 1.14]AUROC: 0.763—age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal c... omponentsShow more—
PPM000604PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Coronary heart disease (incident and prevalent)OR: 1.2 [1.06, 1.35]AUROC: 0.769—age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal c... omponentsShow more—
PPM000614PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Incident coronary heart diseaseHR: 1.2 [1.15, 1.25]C-index: 0.736—sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific prin... cipal componentsShow moreAge-as-time-scale Cox regression
PPM000618PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Incident coronary heart diseaseHR: 1.05 [0.94, 1.18]C-index: 0.704—sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific prin... cipal componentsShow moreAge-as-time-scale Cox regression
PPM000622PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		Reported Trait: Incident coronary heart diseaseHR: 1.12 [0.93, 1.36]C-index: 0.708—sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific prin... cipal componentsShow moreAge-as-time-scale Cox regression
Showing 1 to 15 of 18 rows
1525All
rows per page

Evaluated Samples

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000010Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or ... death due to ischemic heart disease. Show more—
[
  • 2,213 cases
  • , 21,382 controls
]
,
38.03 % Male samples
—European
(Swedish)		—MDCProspective study
PSS000018CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal cor... onary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75.Show more—
[
  • 22,242 cases
  • , 460,387 controls
]
,
45.6 % Male samples
—European, NR~95% European ancestry samples, <5% non-European ancestryUKB—
PSS000283Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary...  causes.Show moreMean = 18.8 years
[
  • 1,230 cases
  • , 6,584 controls
]
,
45.0 % Male samples
Mean = 54.0 years
Sd = 5.7 years		European—ARIC—
PSS000284Cross-sectional analysis of baseline scores for coronary artery calcification (Agatston score)—4,260 individuals,
44.0 % Male samples
Mean = 69.1 years
Sd = 6.0 years		European—BioImage—
PSS000285Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary...  causes.Show moreMean = 19.4 years
[
  • 2,902 cases
  • , 19,487 controls
]
,
38.0 % Male samples
Mean = 58.0 years
Sd = 7.7 years		European—MDC-CC—
PSS000286Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary...  causes.Show moreMean = 20.5 years
[
  • 971 cases
  • , 20,251 controls
]
,
0.0 % Male samples
Mean = 54.2 years
Sd = 7.1 years		European—WGHS—
PSS000331CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization eve... nts (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410Show moreMedian = 9.2 years
IQR = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years		African American or Afro-Caribbean—7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000332CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization eve... nts (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410Show moreMedian = 9.2 years
IQR = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years		African American or Afro-Caribbean—7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000333CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization eve... nts (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410Show moreMedian = 11.7 years
IQR = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years		European—11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization eve... nts (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410Show moreMedian = 11.7 years
IQR = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years		European—11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization eve... nts (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410Show moreMedian = 10.4 years
IQR = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years		Hispanic or Latin American—8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization eve... nts (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410Show moreMedian = 10.4 years
IQR = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years		Hispanic or Latin American—8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS011680At baseline, all individuals were free from coronary heart disease (CHD). Cases included individuals...  who were hospitalised due to CHD or suffered a fatal CHD event. CHD events were defined for non-fatal cases as the International Classification of Diseases ninth revision (ICD-9) codes 410 and 4110 (years 1992-1995) and ICD-10 codes I200, I21 or I22 (1996-2015) and Nordic Medico-Statistical Committee codes for coronary artery bypass graft or percutaneous coronary intervention in the hospital discharge register, and for fatal cases as ICD-9 codes 410-414 and 798 (not 7980A) and ICD-10 codes I20-25, I46, R96 and R98 in the causes of death register.Show moreMean = 13.8 years
[
  • 2,063 cases
  • , 24,140 controls
]
,
46.74 % Male samples
Mean = 48.0 yearsEuropean
(Finnish)		—FINRISK—
Showing 1 to 13 of 13 rows
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.
I agree, dismiss this banner