PGS Publication: PGP000083

Publication Information (EuropePMC)
Title Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups.
PubMed ID 32386537(Europe PMC)
doi 10.1016/j.ajhg.2020.04.002
Publication Date May 1, 2020
Journal Am J Hum Genet
Author(s) Dikilitas O, Schaid DJ, Kosel ML, Carroll RJ, Chute CG, Denny JA, Fedotov A, Feng Q, Hakonarson H, Jarvik GP, Lee MTM, Pacheco JA, Rowley R, Sleiman PM, Stein CM, Sturm AC, Wei WQ, Wiesner GL, Williams MS, Zhang Y, Manolio TA, Kullo IJ.
Released in PGS Catalog: June 3, 2020

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000200
(GRS28)
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Coronary heart disease coronary artery disease 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000200/ScoringFiles/PGS000200.txt.gz
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000011
(GRS50)
 PGP000004 |
Tada H et al. Eur Heart J (2015)
 Coronary artery disease coronary artery disease 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000589 PGS000011
(GRS50)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] C-index: 0.698 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000597 PGS000018
(metaGRS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.53 [1.23, 1.9] C-index: 0.683 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000596 PGS000013
(GPS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.16 [0.96, 1.41] C-index: 0.659 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000595 PGS000011
(GRS50)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.13 [0.93, 1.36] C-index: 0.654 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000594 PGS000018
(metaGRS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.27 [1.13, 1.43] C-index: 0.663 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000593 PGS000013
(GPS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.19 [1.07, 1.33] C-index: 0.656 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000592 PGS000011
(GRS50)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.05 [0.94, 1.17] C-index: 0.649 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000591 PGS000018
(metaGRS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.53 [1.46, 1.6] C-index: 0.719 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000619 PGS000013
(GPS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.17 [1.04, 1.31] C-index: 0.712 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000618 PGS000011
(GRS50)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.05 [0.94, 1.18] C-index: 0.704 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000617 PGS000200
(GRS28)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.11 [0.99, 1.25] C-index: 0.706 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000616 PGS000018
(metaGRS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.49 [1.43, 1.56] C-index: 0.75 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000615 PGS000013
(GPS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.47 [1.41, 1.54] C-index: 0.75 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000614 PGS000011
(GRS50)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] C-index: 0.736 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000613 PGS000200
(GRS28)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.17 [1.12, 1.22] C-index: 0.735 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000620 PGS000018
(metaGRS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.25 [1.12, 1.41] C-index: 0.723 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000624 PGS000018
(metaGRS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.5 [1.21, 1.87] C-index: 0.725 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000623 PGS000013
(GPS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.39] C-index: 0.708 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000622 PGS000011
(GRS50)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.12 [0.93, 1.36] C-index: 0.708 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000621 PGS000200
(GRS28)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.13 [0.93, 1.37] C-index: 0.709 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000590 PGS000013
(GPS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.5 [1.43, 1.56] C-index: 0.719 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000607 PGS000200
(GRS28)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.18 [1.13, 1.23] C-index: 0.697 — sex, eMERGE site, first five ancestry-specific principal components —
PPM000608 PGS000200
(GRS28)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.11 [0.99, 1.24] C-index: 0.652 — sex, eMERGE site, first five ancestry-specific principal components —
PPM000605 PGS000013
(GPS_CAD)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.42 [1.25, 1.61] AUROC: 0.776 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000604 PGS000011
(GRS50)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.2 [1.06, 1.35] AUROC: 0.769 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000603 PGS000018
(metaGRS_CAD)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.4 [1.3, 1.52] AUROC: 0.775 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000602 PGS000013
(GPS_CAD)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.3 [1.21, 1.41] AUROC: 0.771 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000601 PGS000011
(GRS50)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.05 [0.98, 1.14] AUROC: 0.763 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000600 PGS000018
(metaGRS_CAD)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.73 [1.68, 1.78] AUROC: 0.772 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000599 PGS000013
(GPS_CAD)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.66 [1.62, 1.71] AUROC: 0.77 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000598 PGS000011
(GRS50)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.28 [1.25, 1.32] AUROC: 0.75 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000612 PGS000200
(GRS28)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.27 [1.12, 1.42] AUROC: 0.771 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000611 PGS000200
(GRS28)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.07 [0.99, 1.16] AUROC: 0.763 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000610 PGS000200
(GRS28)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.24 [1.21, 1.28] AUROC: 0.748 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000609 PGS000200
(GRS28)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.37] C-index: 0.655 — sex, eMERGE site, first five ancestry-specific principal components —
PPM000606 PGS000018
(metaGRS_CAD)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.93 [1.67, 2.22] AUROC: 0.794 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000331 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
IQR = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
 Mean = 43.6 years
Sd = 12.5 years		 African American or Afro-Caribbean — 7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000332 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
IQR = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
 Mean = 43.6 years
Sd = 12.5 years		 African American or Afro-Caribbean — 7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000333 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
IQR = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
 Mean = 49.0 years
Sd = 14.1 years		 European — 11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
IQR = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
 Mean = 49.0 years
Sd = 14.1 years		 European — 11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
IQR = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
 Mean = 41.1 years
Sd = 13.2 years		 Hispanic or Latin American — 8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
IQR = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
 Mean = 41.1 years
Sd = 13.2 years		 Hispanic or Latin American — 8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)