Polygenic Score (PGS) ID: PGS002810

Predicted Trait
Reported Trait Estimated glomerular filtration rate
Mapped Trait(s) glomerular filtration rate (EFO_0005208)
Released in PGS Catalog: Nov. 7, 2022
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Score Details

Score Construction
PGS Name GRS147_eGFR
Development Method
Name Genome-wide significant SNPs
Parameters Index SNPs likely relevant for kidney function
Variants
Original Genome Build GRCh37
Number of Variants 147
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000390
Citation (link to publication) Wuttke M et al. Nat Genet (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 74.1%
East Asian: 21.7%
African: 1.8%
South Asian: 1.7%
Hispanic or Latin American: 0.6%
765,348 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008058
Europe PMC: 31152163
 567,460 individuals European NR
GWAS Catalog: GCST008058
Europe PMC: 31152163
 165,726 individuals East Asian NR
GWAS Catalog: GCST008058
Europe PMC: 31152163
 13,842 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST008058
Europe PMC: 31152163
 13,359 individuals South Asian NR
GWAS Catalog: GCST008058
Europe PMC: 31152163
 4,961 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015582 PSS009991|
European Ancestry|
452,264 individuals
 PGP000390 |
Wuttke M et al. Nat Genet (2019)
 Reported Trait: Chronic renal failure — — Odds ratio (OR, 10% lower vs higher): 2.13 [1.9, 2.39] — —
PPM015583 PSS009991|
European Ancestry|
452,264 individuals
 PGP000390 |
Wuttke M et al. Nat Genet (2019)
 Reported Trait: Urolithiasis — — Odds ratio (OR, 10% lower vs higher): 0.75 [0.69, 0.83] — —
PPM015584 PSS009991|
European Ancestry|
452,264 individuals
 PGP000390 |
Wuttke M et al. Nat Genet (2019)
 Reported Trait: Hypertensive diseases — — Odds ratio (OR, 10% lower vs higher): 1.07 [1.04, 1.1] — —
PPM015585 PSS009991|
European Ancestry|
452,264 individuals
 PGP000390 |
Wuttke M et al. Nat Genet (2019)
 Reported Trait: Ischemic heart disease — — Odds ratio (OR, 10% lower vs higher): 0.96 [0.92, 1.0] — —
PPM015580 PSS009991|
European Ancestry|
452,264 individuals
 PGP000390 |
Wuttke M et al. Nat Genet (2019)
 Reported Trait: Acute renal failure — — Odds ratio (OR, 10% lower vs higher): 1.3 [1.16, 1.47] — —
PPM015581 PSS009991|
European Ancestry|
452,264 individuals
 PGP000390 |
Wuttke M et al. Nat Genet (2019)
 Reported Trait: Glomerular disease — — Odds ratio (OR, 10% lower vs higher): 1.45 [1.22, 1.71] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009991 glomerular diseases (ICD-10 codes N00-N08; 2,289 cases); acute renal failure (N17; 4,913 cases); chronic renal failure (N18; 4,905 cases); urolithiasis (N20-N23; 7,053 cases); hypertensive diseases (I10-I15; 84,910 cases); and ischemic heart diseases (I20-I25; 33,387 cases). Asthma (J45; 28,628 cases) was included as a negative control. — 452,264 individuals — European — UKB —