Trait: glomerular filtration rate

Trait Information
Identifier OBA_0003747
Description The rate of a glomerular filtration. [AUTO: patterns/patterns/entity_attribute]
Trait category
Other measurement
Synonym rate of glomerular filtration

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000303
(GRS253_eGFR)
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Estimated glomerular filtration rateglomerular filtration rate253
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000303/ScoringFiles/PGS000303.txt.gz
PGS000682
(snpnet.eGFR)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
eGFR [ml/min/1.73m2]glomerular filtration rate17,467
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000682/ScoringFiles/PGS000682.txt.gz - Check Terms/Licenses
PGS000860
(eGFR)
PGP000211 |
Aly DM et al. Nat Genet (2021)
Estimated glomerular filtration rateglomerular filtration rate625
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000860/ScoringFiles/PGS000860.txt.gz
PGS000883
(eGFR_LDpredPRS)
PGP000229 |
Yu Z et al. J Am Soc Nephrol (2021)
Estimated glomerular filtration rateglomerular filtration rate1,477,661
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000883/ScoringFiles/PGS000883.txt.gz
PGS000884
(eGFR_PTPRS)
PGP000229 |
Yu Z et al. J Am Soc Nephrol (2021)
Estimated glomerular filtration rateglomerular filtration rate40,042
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000884/ScoringFiles/PGS000884.txt.gz
PGS000885
(eGFR_TOPSNPPRS)
PGP000229 |
Yu Z et al. J Am Soc Nephrol (2021)
Estimated glomerular filtration rateglomerular filtration rate1,460
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000885/ScoringFiles/PGS000885.txt.gz
PGS002810
(GRS147_eGFR)
PGP000390 |
Wuttke M et al. Nat Genet (2019)
Estimated glomerular filtration rateglomerular filtration rate147
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002810/ScoringFiles/PGS002810.txt.gz
PGS003219
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate443,281
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003219/ScoringFiles/PGS003219.txt.gz
PGS003220
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate2,439
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003220/ScoringFiles/PGS003220.txt.gz
PGS003221
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate2,491
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003221/ScoringFiles/PGS003221.txt.gz
PGS003222
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate4,656,243
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003222/ScoringFiles/PGS003222.txt.gz
PGS003223
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate1,117,334
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003223/ScoringFiles/PGS003223.txt.gz
PGS003224
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_LASSOSUM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate456,946
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003224/ScoringFiles/PGS003224.txt.gz
PGS003225
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_PT_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate2,092
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003225/ScoringFiles/PGS003225.txt.gz
PGS003226
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_PLINK_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate2,127
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003226/ScoringFiles/PGS003226.txt.gz
PGS003227
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_DBSLMM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate4,728,961
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003227/ScoringFiles/PGS003227.txt.gz
PGS003228
(ExPRSweb_eGFR_20171017-MW-eGFR-EA_PRSCS_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rateglomerular filtration rate1,118,118
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003228/ScoringFiles/PGS003228.txt.gz
PGS003249
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		202,159
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003249/ScoringFiles/PGS003249.txt.gz
PGS003250
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		108
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003250/ScoringFiles/PGS003250.txt.gz
PGS003251
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		108
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003251/ScoringFiles/PGS003251.txt.gz
PGS003252
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		59,729
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003252/ScoringFiles/PGS003252.txt.gz
PGS003253
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		1,109,085
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003253/ScoringFiles/PGS003253.txt.gz
PGS003254
(ExPRSweb_Creatine_eGFRcrea-overall-EA_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		2,986
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003254/ScoringFiles/PGS003254.txt.gz
PGS003255
(ExPRSweb_Creatine_eGFRcrea-overall-EA_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		352
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003255/ScoringFiles/PGS003255.txt.gz
PGS003256
(ExPRSweb_Creatine_eGFRcrea-overall-EA_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		641
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003256/ScoringFiles/PGS003256.txt.gz
PGS003257
(ExPRSweb_Creatine_eGFRcrea-overall-EA_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		3,145
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003257/ScoringFiles/PGS003257.txt.gz
PGS003258
(ExPRSweb_Creatine_eGFRcrea-overall-EA_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		16,682
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003258/ScoringFiles/PGS003258.txt.gz
PGS003259
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		87,064
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003259/ScoringFiles/PGS003259.txt.gz
PGS003260
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		234
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003260/ScoringFiles/PGS003260.txt.gz
PGS003261
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		234
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003261/ScoringFiles/PGS003261.txt.gz
PGS003262
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		1,005,540
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003262/ScoringFiles/PGS003262.txt.gz
PGS003263
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		932,548
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003263/ScoringFiles/PGS003263.txt.gz
PGS003264
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_LASSOSUM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		214,280
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003264/ScoringFiles/PGS003264.txt.gz
PGS003265
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_PT_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		176
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003265/ScoringFiles/PGS003265.txt.gz
PGS003266
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_PLINK_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		176
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003266/ScoringFiles/PGS003266.txt.gz
PGS003267
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_DBSLMM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		22,376
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003267/ScoringFiles/PGS003267.txt.gz
PGS003268
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_PRSCS_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		1,109,812
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003268/ScoringFiles/PGS003268.txt.gz
PGS003269
(ExPRSweb_Creatine_eGFRcrea-overall-EA_LASSOSUM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		2,989
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003269/ScoringFiles/PGS003269.txt.gz
PGS003270
(ExPRSweb_Creatine_eGFRcrea-overall-EA_PT_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		314
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003270/ScoringFiles/PGS003270.txt.gz
PGS003271
(ExPRSweb_Creatine_eGFRcrea-overall-EA_PLINK_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		600
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003271/ScoringFiles/PGS003271.txt.gz
PGS003272
(ExPRSweb_Creatine_eGFRcrea-overall-EA_DBSLMM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		2,305
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003272/ScoringFiles/PGS003272.txt.gz
PGS003273
(ExPRSweb_Creatine_eGFRcrea-overall-EA_PRSCS_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		16,686
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003273/ScoringFiles/PGS003273.txt.gz
PGS003274
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_LASSOSUM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		87,693
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003274/ScoringFiles/PGS003274.txt.gz
PGS003275
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_PT_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		458
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003275/ScoringFiles/PGS003275.txt.gz
PGS003276
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_PLINK_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		458
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003276/ScoringFiles/PGS003276.txt.gz
PGS003277
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_DBSLMM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		963,494
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003277/ScoringFiles/PGS003277.txt.gz
PGS003278
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_PRSCS_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Creatine)creatine measurement,
glomerular filtration rate		932,878
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003278/ScoringFiles/PGS003278.txt.gz
PGS003289
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Cystatin C)cystatin C measurement,
glomerular filtration rate		162,595
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003289/ScoringFiles/PGS003289.txt.gz
PGS003290
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Cystatin C)cystatin C measurement,
glomerular filtration rate		48
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003290/ScoringFiles/PGS003290.txt.gz
PGS003291
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Estimated glomerular filtration rate (Cystatin C)cystatin C measurement,
glomerular filtration rate		49
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003291/ScoringFiles/PGS003291.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM000773PGS000303
(GRS253_eGFR)
PSS000376|
European Ancestry|
1,354 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Estimated glomerular filtration rate (mL/min per 1.73 m2)——R²: 0.0504Sex, age—
PPM001410PGS000682
(snpnet.eGFR)
PSS000805|
African Ancestry|
6,016 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: eGFR [ml/min/1.73m2]——R²: 0.17769
Spearman's ρ: 0.138		Age, sex, PCs(1-40)—
PPM001445PGS000682
(snpnet.eGFR)
PSS000806|
East Asian Ancestry|
1,081 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: eGFR [ml/min/1.73m2]——R²: 0.21054
Spearman's ρ: 0.199		Age, sex, PCs(1-40)—
PPM001480PGS000682
(snpnet.eGFR)
PSS000807|
European Ancestry|
23,576 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: eGFR [ml/min/1.73m2]——R²: 0.25538
Spearman's ρ: 0.299		Age, sex, PCs(1-40)—
PPM001515PGS000682
(snpnet.eGFR)
PSS000808|
South Asian Ancestry|
7,339 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: eGFR [ml/min/1.73m2]——R²: 0.23182
Spearman's ρ: 0.252		Age, sex, PCs(1-40)—
PPM001550PGS000682
(snpnet.eGFR)
PSS000809|
European Ancestry|
63,758 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: eGFR [ml/min/1.73m2]——R²: 0.24611
Spearman's ρ: 0.313		Age, sex, PCs(1-40)—
PPM001592PGS000682
(snpnet.eGFR)
PSS000810|
European Ancestry|
2,129 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: eGFR [ml/min/1.73m2]——Spearman's ρ: 0.219Age, sex—
PPM002383PGS000860
(eGFR)
PSS001086|
European Ancestry|
3,194 individuals
PGP000211 |
Aly DM et al. Nat Genet (2021)
Reported Trait: Severe Autoimmune DiabetesOR: 1.04 [0.94, 1.15]——PC1-10—
PPM002384PGS000860
(eGFR)
PSS001087|
European Ancestry|
3,930 individuals
PGP000211 |
Aly DM et al. Nat Genet (2021)
Reported Trait: Severe Insulin-Deficient DiabetesOR: 1.02 [0.96, 1.1]——PC1-10—
PPM002385PGS000860
(eGFR)
PSS001088|
European Ancestry|
3,869 individuals
PGP000211 |
Aly DM et al. Nat Genet (2021)
Reported Trait: Severe Insulin-Resistant DiabetesOR: 1.04 [0.97, 1.11]——PC1-10—
PPM002386PGS000860
(eGFR)
PSS001085|
European Ancestry|
4,116 individuals
PGP000211 |
Aly DM et al. Nat Genet (2021)
Reported Trait: Moderate Obesity-related DiabetesOR: 1.03 [0.96, 1.1]——PC1-10—
PPM002387PGS000860
(eGFR)
PSS001084|
European Ancestry|
5,597 individuals
PGP000211 |
Aly DM et al. Nat Genet (2021)
Reported Trait: Moderate Age-Related DiabetesOR: 1.07 [1.02, 1.13]——PC1-10—
PPM002528PGS000883
(eGFR_LDpredPRS)
PSS001143|
European Ancestry|
8,886 individuals
PGP000229 |
Yu Z et al. J Am Soc Nephrol (2021)
Reported Trait: Incident chronic kidney diseaseHR: 1.32AUROC: 0.677—age at baseline, sex, center, first 10 genetic principal components, education, baseline body mass ... index, baseline smoking status, baseline history of hypertension, diabetes, and coronary heart diseaseShow more—
PPM002529PGS000883
(eGFR_LDpredPRS)
PSS001143|
European Ancestry|
8,886 individuals
PGP000229 |
Yu Z et al. J Am Soc Nephrol (2021)
Reported Trait: Incident end stage kidney diseaseHR: 1.24——age at baseline, sex, center, first 10 genetic principal components, education, baseline body mass ... index, baseline smoking status, baseline history of hypertension, diabetes, and coronary heart diseaseShow more—
PPM002530PGS000883
(eGFR_LDpredPRS)
PSS001143|
European Ancestry|
8,886 individuals
PGP000229 |
Yu Z et al. J Am Soc Nephrol (2021)
Reported Trait: Incident kidney failureHR: 1.17——age at baseline, sex, center, first 10 genetic principal components, education, baseline body mass ... index, baseline smoking status, baseline history of hypertension, diabetes, and coronary heart diseaseShow more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000376We measured weight and height using regularly calibrated equipment (scales and stadiometer models 77... 0 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA).Show more—1,354 individuals,
47.56 % Male samples
Mean = 16.22 years
Sd = 0.66 years		European—TRAILS—
PSS000805——6,016 individuals—African unspecified—UKB—
PSS000806——1,081 individuals—East Asian—UKB—
PSS000807——23,576 individuals—EuropeanNon-British WhiteUKB—
PSS000808——7,339 individuals—South Asian—UKB—
PSS000809——63,758 individuals—European
(British)		—UKB—
PSS000810——2,129 individuals—EuropeanParticipants self-identifying as whiteMESA—
PSS001084Moderate Age-Related Diabetes (MARD) vs. controls—
[
  • 2,853 cases
  • , 2,744 controls
]
—EuropeanSwedishANDIS—
PSS001085Moderate Obesity-related Diabetes (MOD) vs. controls—
[
  • 1,372 cases
  • , 2,744 controls
]
—EuropeanSwedishANDIS—
PSS001086Severe Autoimmune Diabetes (SAID) vs. controls—
[
  • 450 cases
  • , 2,744 controls
]
—EuropeanSwedishANDIS—
PSS001087Severe Insulin-Deficient Diabetes (SIDD) vs. controls—
[
  • 1,186 cases
  • , 2,744 controls
]
—EuropeanSwedishANDIS—
PSS001088Severe Insulin-Resistant Diabetes (SIRD) vs. controls—
[
  • 1,125 cases
  • , 2,744 controls
]
—EuropeanSwedishANDIS—
PSS001143log transformed eGFR based on 2012 CKD-EPI creatinine equationMean = 30.0 years8,886 individuals,
0.47 % Male samples
Mean = 54.3 yearsEuropean—ARIC—
PSS006911——6,016 individuals—African unspecified—UKB—
PSS006912——1,578 individuals—East Asian—UKB—
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