| Publication Information (EuropePMC) | |
| Title | Genetic Risk Scores for Complex Disease Traits in Youth. |
| PubMed ID | 32527150(Europe PMC) |
| doi | 10.1161/circgen.119.002775 |
| Publication Date | June 11, 2020 |
| Journal | Circ Genom Precis Med |
| Author(s) | Xie T, Wang B, Nolte IM, van der Most PJ, Oldehinkel AJ, Hartman CA, Snieder H. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000306 (GRS19_FGadjBMI) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Fasting glucose (body mass index adjusted) | BMI-adjusted fasting blood glucose measurement | 19 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000306/ScoringFiles/PGS000306.txt.gz |
| PGS000303 (GRS253_eGFR) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Estimated glomerular filtration rate | glomerular filtration rate | 253 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000303/ScoringFiles/PGS000303.txt.gz |
| PGS000307 (GRS12_FI) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Fasting insulin | fasting blood insulin measurement | 12 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000307/ScoringFiles/PGS000307.txt.gz |
| PGS000300 (GRS80_HR) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Heart rate | resting heart rate | 80 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000300/ScoringFiles/PGS000300.txt.gz |
| PGS000305 (GRS31_FG) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Fasting glucose | fasting blood glucose measurement | 31 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000305/ScoringFiles/PGS000305.txt.gz |
| PGS000301 (GRS970_SBP) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Systolic blood pressure | systolic blood pressure | 970 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000301/ScoringFiles/PGS000301.txt.gz |
| PGS000302 (GRS962_DBP) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Diastolic blood pressure | diastolic blood pressure | 962 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000302/ScoringFiles/PGS000302.txt.gz |
| PGS000311 (GRS234_TC) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Total cholesterol | total cholesterol measurement | 234 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000311/ScoringFiles/PGS000311.txt.gz |
| PGS000312 (GRS190_TG) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Triglycerides | triglyceride measurement | 190 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000312/ScoringFiles/PGS000312.txt.gz |
| PGS000313 (GRS49_Lp(a)) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Lipoprotein A | lipoprotein A measurement | 49 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000313/ScoringFiles/PGS000313.txt.gz |
| PGS000314 (GRS77_CRP) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
C-reactive protein | C-reactive protein measurement | 77 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000314/ScoringFiles/PGS000314.txt.gz |
| PGS000297 (GRS3290_Height) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Height | body height | 3,290 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000297/ScoringFiles/PGS000297.txt.gz |
| PGS000298 (GRS941_BMI) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Body mass index (BMI) | body mass index | 941 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000298/ScoringFiles/PGS000298.txt.gz |
| PGS000299 (GRS462_WHRadjBMI) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Waist-to-hip ratio (body mass index adjusted) | BMI-adjusted waist-hip ratio | 462 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000299/ScoringFiles/PGS000299.txt.gz |
| PGS000304 (GRS43_HbA1c) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
HbA1c | HbA1c measurement | 43 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000304/ScoringFiles/PGS000304.txt.gz |
| PGS000308 (GRS12_FIadjBMI) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Fasting insulin (body mass index adjusted) | BMI-adjusted fasting blood insulin measurement | 12 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000308/ScoringFiles/PGS000308.txt.gz |
| PGS000309 (GRS247_HDL) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
HDL cholesterol | high density lipoprotein cholesterol measurement | 247 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000309/ScoringFiles/PGS000309.txt.gz |
| PGS000310 (GRS194_LDL) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
LDL cholesterol | low density lipoprotein cholesterol measurement | 194 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000310/ScoringFiles/PGS000310.txt.gz |
| PGS000315 (GRS7_lgE) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Immunoglobulin E (IgE) | serum IgE measurement | 7 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000315/ScoringFiles/PGS000315.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000779 | PGS000309 (GRS247_HDL) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: High-density lipoprotein (mmol/l) | — | — | R²: 0.1149 | Sex, age, age^2 | — |
| PPM000772 | PGS000302 (GRS962_DBP) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Diastolic blood pressure (mmHg) | — | — | R²: 0.0448 | Sex, age, age^2, BMI | — |
| PPM000778 | PGS000308 (GRS12_FIadjBMI) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Fasting insulin (mU/I) | — | — | R²: 0.0069 | Sex, age, BMI | — |
| PPM000780 | PGS000310 (GRS194_LDL) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Low-density lipoprotein (mmol/l) | — | — | R²: 0.1849 | Sex, age, age^2 | — |
| PPM000781 | PGS000311 (GRS234_TC) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Total cholesterol (mmol/l) | — | — | R²: 0.1295 | Sex, age, age^2 | — |
| PPM000782 | PGS000312 (GRS190_TG) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Triglycerides (mmol/l) | — | — | R²: 0.0656 | Sex, age, age^2 | — |
| PPM000783 | PGS000313 (GRS49_Lp(a)) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Lipoprotein(a) (mg/l) | — | — | R²: 0.3959 | Sex, age, age^2 | — |
| PPM000784 | PGS000314 (GRS77_CRP) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: C-reactive protein (mg/l) | — | — | R²: 0.0369 | Sex, age | — |
| PPM000791 | PGS000298 (GRS941_BMI) |
PSS000369| European Ancestry| 334 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.0671 | Sex, age | — |
| PPM000792 | PGS000298 (GRS941_BMI) |
PSS000370| European Ancestry| 329 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.057 | Sex, age | — |
| PPM000793 | PGS000298 (GRS941_BMI) |
PSS000371| European Ancestry| 288 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.0886 | Sex, age | — |
| PPM000794 | PGS000298 (GRS941_BMI) |
PSS000372| European Ancestry| 265 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.092 | Sex, age | — |
| PPM000795 | PGS000298 (GRS941_BMI) |
PSS000373| European Ancestry| 245 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.1194 | Sex, age | — |
| PPM000801 | PGS000301 (GRS970_SBP) |
PSS000371| European Ancestry| 288 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Systolic blood pressure (mmHg) | — | — | R²: 0.012 | Sex, age, age^2, BMI | — |
| PPM000802 | PGS000302 (GRS962_DBP) |
PSS000371| European Ancestry| 288 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Diastolic blood pressure (mmHg) | — | — | R²: 0.0088 | Sex, age, age^2, BMI | — |
| PPM000763 | PGS000298 (GRS941_BMI) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.0647 | Sex, age | — |
| PPM000764 | PGS000298 (GRS941_BMI) |
PSS000377| European Ancestry| 1,174 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.0655 | Sex, age | — |
| PPM000765 | PGS000298 (GRS941_BMI) |
PSS000378| European Ancestry| 1,095 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.0591 | Sex, age | — |
| PPM000762 | PGS000298 (GRS941_BMI) |
PSS000375| European Ancestry| 1,313 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.0612 | Sex, age | — |
| PPM000757 | PGS000297 (GRS3290_Height) |
PSS000375| European Ancestry| 1,313 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.1172 | Sex, age | — |
| PPM000758 | PGS000297 (GRS3290_Height) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.1368 | Sex, age | — |
| PPM000759 | PGS000297 (GRS3290_Height) |
PSS000377| European Ancestry| 1,174 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.1273 | Sex, age | — |
| PPM000760 | PGS000297 (GRS3290_Height) |
PSS000378| European Ancestry| 1,095 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.1382 | Sex, age | — |
| PPM000766 | PGS000299 (GRS462_WHRadjBMI) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Waist-to-hip ratio | — | — | R²: 0.0138 | Sex, age, age^2, BMI | — |
| PPM000767 | PGS000299 (GRS462_WHRadjBMI) |
PSS000377| European Ancestry| 1,174 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Waist-to-hip ratio | — | — | R²: 0.0141 | Sex, age, age^2, BMI | — |
| PPM000768 | PGS000299 (GRS462_WHRadjBMI) |
PSS000378| European Ancestry| 1,095 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Waist-to-hip ratio | — | — | R²: 0.0195 | Sex, age, age^2, BMI | — |
| PPM000769 | PGS000300 (GRS80_HR) |
PSS000374| European Ancestry| 1,318 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Heart rate (bpm) | — | — | R²: 0.0211 | Sex, age, age^2, BMI | — |
| PPM000761 | PGS000298 (GRS941_BMI) |
PSS000374| European Ancestry| 1,318 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Body mass index (kg/m2) | — | — | R²: 0.0579 | Sex, age | — |
| PPM000756 | PGS000297 (GRS3290_Height) |
PSS000374| European Ancestry| 1,318 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.1192 | Sex, age | — |
| PPM000771 | PGS000301 (GRS970_SBP) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Systolic blood pressure (mmHg) | — | — | R²: 0.0215 | Sex, age, age^2, BMI | — |
| PPM000773 | PGS000303 (GRS253_eGFR) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Estimated glomerular filtration rate (mL/min per 1.73 m2) | — | — | R²: 0.0504 | Sex, age | — |
| PPM000770 | PGS000300 (GRS80_HR) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Heart rate (bpm) | — | — | R²: 0.0146 | Sex, age, age^2, BMI | — |
| PPM000776 | PGS000306 (GRS19_FGadjBMI) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Fasting glucose (mmol/l) | — | — | R²: 0.0095 | Sex, age, BMI | — |
| PPM000774 | PGS000304 (GRS43_HbA1c) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: HbA1c (%) | — | — | R²: 0.0283 | Sex, age, age^2 | — |
| PPM000775 | PGS000305 (GRS31_FG) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Fasting glucose (mmol/l) | — | — | R²: 0.0367 | Sex, age, age^2 | — |
| PPM000785 | PGS000315 (GRS7_lgE) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Immunoglobulin E (kU/I) | — | — | R²: 0.0206 | Sex, age | — |
| PPM000786 | PGS000297 (GRS3290_Height) |
PSS000369| European Ancestry| 334 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.087 | Sex, age | — |
| PPM000787 | PGS000297 (GRS3290_Height) |
PSS000370| European Ancestry| 329 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.0755 | Sex, age | — |
| PPM000788 | PGS000297 (GRS3290_Height) |
PSS000371| European Ancestry| 288 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.0887 | Sex, age | — |
| PPM000789 | PGS000297 (GRS3290_Height) |
PSS000372| European Ancestry| 265 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.0986 | Sex, age | — |
| PPM000790 | PGS000297 (GRS3290_Height) |
PSS000373| European Ancestry| 245 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Height (cm) | — | — | R²: 0.1158 | Sex, age | — |
| PPM000796 | PGS000299 (GRS462_WHRadjBMI) |
PSS000371| European Ancestry| 288 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Waist-to-hip ratio | — | — | R²: 0.01 | Sex, age, age^2, BMI | — |
| PPM000797 | PGS000299 (GRS462_WHRadjBMI) |
PSS000372| European Ancestry| 265 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Waist-to-hip ratio | — | — | R²: 0.017 | Sex, age, age^2, BMI | — |
| PPM000798 | PGS000299 (GRS462_WHRadjBMI) |
PSS000373| European Ancestry| 245 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Waist-to-hip ratio | — | — | R²: 0.0156 | Sex, age, age^2, BMI | — |
| PPM000799 | PGS000300 (GRS80_HR) |
PSS000369| European Ancestry| 334 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Heart rate (bpm) | — | — | R²: 0.0028 | Sex, age, age^2, BMI | — |
| PPM000800 | PGS000300 (GRS80_HR) |
PSS000371| European Ancestry| 288 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Heart rate (bpm) | — | — | R²: 0.0223 | Sex, age, age^2, BMI | — |
| PPM000803 | PGS000304 (GRS43_HbA1c) |
PSS000371| European Ancestry| 288 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: HbA1c (%) | — | — | R²: 0.0277 | Sex, age, age^2 | — |
| PPM000777 | PGS000307 (GRS12_FI) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Fasting insulin (mU/I) | — | — | R²: 0.0145 | Sex, age | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000369 | Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 334 individuals, 69.2 % Male samples |
Mean = 11.1 years Sd = 0.48 years |
European | — | TRAILS, TRAILSCC | TRAILS Clinical Cohort |
| PSS000370 | Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 329 individuals, 69.2 % Male samples |
Mean = 12.81 years Sd = 0.59 years |
European | — | TRAILS, TRAILSCC | TRAILS Clinical Cohort |
| PSS000371 | Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 288 individuals, 69.2 % Male samples |
Mean = 15.83 years Sd = 0.6 years |
European | — | TRAILS, TRAILSCC | TRAILS Clinical Cohort |
| PSS000372 | Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 265 individuals, 69.2 % Male samples |
Mean = 19.2 years Sd = 0.66 years |
European | — | TRAILS, TRAILSCC | TRAILS Clinical Cohort |
| PSS000373 | Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 245 individuals, 69.2 % Male samples |
Mean = 22.04 years Sd = 0.69 years |
European | — | TRAILS, TRAILSCC | TRAILS Clinical Cohort |
| PSS000374 | We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 1,318 individuals, 47.6 % Male samples |
Mean = 11.1 years | European | — | TRAILS | — |
| PSS000375 | We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 1,313 individuals, 47.6 % Male samples |
Mean = 13.5 years | European | — | TRAILS | — |
| PSS000376 | We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 1,354 individuals, 47.56 % Male samples |
Mean = 16.22 years Sd = 0.66 years |
European | — | TRAILS | — |
| PSS000377 | We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 1,174 individuals, 47.6 % Male samples |
Mean = 19.2 years | European | — | TRAILS | — |
| PSS000378 | We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 1,095 individuals, 47.6 % Male samples |
Mean = 22.4 years | European | — | TRAILS | — |