| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0004458 |
| Description |
|
Trait category |
Inflammatory measurement
|
| Synonym | C-reactive protein level |
| Mapped terms |
2 mapped terms
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000314 (GRS77_CRP) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
C-reactive protein | C-reactive protein measurement | 77 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000314/ScoringFiles/PGS000314.txt.gz |
| PGS000675 (snpnet.C_reactive_protein) |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
C-reactive protein [mg/L] | C-reactive protein measurement | 17,378 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000675/ScoringFiles/PGS000675.txt.gz |
| PGS001946 (portability-PLR_log_CRP) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 71,444 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001946/ScoringFiles/PGS001946.txt.gz |
| PGS002164 (portability-ldpred2_log_CRP) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 736,345 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002164/ScoringFiles/PGS002164.txt.gz |
| PGS002860 (ExPRSweb_CRP_28887542-GCST004941_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 579,046 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002860/ScoringFiles/PGS002860.txt.gz | |
| PGS002861 (ExPRSweb_CRP_28887542-GCST004941_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 414,578 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002861/ScoringFiles/PGS002861.txt.gz | |
| PGS002862 (ExPRSweb_CRP_28887542-GCST004941_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 407,315 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002862/ScoringFiles/PGS002862.txt.gz | |
| PGS002863 (ExPRSweb_CRP_28887542-GCST004941_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 1,118,117 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002863/ScoringFiles/PGS002863.txt.gz | |
| PGS002864 (ExPRSweb_CRP_30710-irnt_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 763,400 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002864/ScoringFiles/PGS002864.txt.gz | |
| PGS002865 (ExPRSweb_CRP_30710-irnt_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 9,373 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002865/ScoringFiles/PGS002865.txt.gz | |
| PGS002866 (ExPRSweb_CRP_30710-irnt_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 13,371 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002866/ScoringFiles/PGS002866.txt.gz | |
| PGS002867 (ExPRSweb_CRP_30710-irnt_DBSLMM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 10,306,310 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002867/ScoringFiles/PGS002867.txt.gz | |
| PGS002868 (ExPRSweb_CRP_30710-irnt_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 1,113,831 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002868/ScoringFiles/PGS002868.txt.gz | |
| PGS002869 (ExPRSweb_CRP_30710-raw_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 481,279 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002869/ScoringFiles/PGS002869.txt.gz | |
| PGS002870 (ExPRSweb_CRP_30710-raw_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 630 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002870/ScoringFiles/PGS002870.txt.gz | |
| PGS002871 (ExPRSweb_CRP_30710-raw_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 837 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002871/ScoringFiles/PGS002871.txt.gz | |
| PGS002872 (ExPRSweb_CRP_30710-raw_DBSLMM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 10,306,271 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002872/ScoringFiles/PGS002872.txt.gz | |
| PGS002873 (ExPRSweb_CRP_30710-raw_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 1,113,831 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002873/ScoringFiles/PGS002873.txt.gz | |
| PGS002874 (ExPRSweb_CRP_prot-a-670_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 316,203 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002874/ScoringFiles/PGS002874.txt.gz | |
| PGS002875 (ExPRSweb_CRP_prot-a-670_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 5 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002875/ScoringFiles/PGS002875.txt.gz | |
| PGS002876 (ExPRSweb_CRP_prot-a-670_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 5 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002876/ScoringFiles/PGS002876.txt.gz | |
| PGS002877 (ExPRSweb_CRP_prot-a-670_DBSLMM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 1,662,602 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002877/ScoringFiles/PGS002877.txt.gz | |
| PGS002878 (ExPRSweb_CRP_prot-a-670_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 1,113,794 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002878/ScoringFiles/PGS002878.txt.gz | |
| PGS002879 (ExPRSweb_CRP_28887542-GCST004941_LASSOSUM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 721,243 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002879/ScoringFiles/PGS002879.txt.gz | |
| PGS002880 (ExPRSweb_CRP_28887542-GCST004941_PT_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 2 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002880/ScoringFiles/PGS002880.txt.gz | |
| PGS002881 (ExPRSweb_CRP_28887542-GCST004941_PLINK_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 2 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002881/ScoringFiles/PGS002881.txt.gz | |
| PGS002882 (ExPRSweb_CRP_28887542-GCST004941_DBSLMM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 746 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002882/ScoringFiles/PGS002882.txt.gz | |
| PGS002883 (ExPRSweb_CRP_28887542-GCST004941_PRSCS_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 1,119,064 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002883/ScoringFiles/PGS002883.txt.gz | |
| PGS002884 (ExPRSweb_CRP_prot-a-670_LASSOSUM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 370,520 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002884/ScoringFiles/PGS002884.txt.gz | |
| PGS002885 (ExPRSweb_CRP_prot-a-670_PT_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 5 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002885/ScoringFiles/PGS002885.txt.gz | |
| PGS002886 (ExPRSweb_CRP_prot-a-670_PLINK_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 5 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002886/ScoringFiles/PGS002886.txt.gz | |
| PGS002887 (ExPRSweb_CRP_prot-a-670_DBSLMM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 444,857 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002887/ScoringFiles/PGS002887.txt.gz | |
| PGS002888 (ExPRSweb_CRP_prot-a-670_PRSCS_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
C-reactive protein | C-reactive protein measurement | 1,114,754 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002888/ScoringFiles/PGS002888.txt.gz | |
| PGS003527 (cont-decay-log_CRP) |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
C-reactive protein | C-reactive protein measurement | 979,739 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003527/ScoringFiles/PGS003527.txt.gz |
| PGS004335 (X30710.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
C-reactive protein (mg/L) | C-reactive protein measurement | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004335/ScoringFiles/PGS004335.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000784 | PGS000314 (GRS77_CRP) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: C-reactive protein (mg/l) | — | — | R²: 0.0369 | Sex, age | — |
| PPM001438 | PGS000675 (snpnet.C_reactive_protein) |
PSS000653| East Asian Ancestry| 1,077 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: C-reactive protein [mg/L] | — | — | R²: 0.10659 Spearman's ρ: 0.274 |
Age, sex, PCs(1-40) | — |
| PPM001473 | PGS000675 (snpnet.C_reactive_protein) |
PSS000654| European Ancestry| 23,534 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: C-reactive protein [mg/L] | — | — | R²: 0.15954 Spearman's ρ: 0.346 |
Age, sex, PCs(1-40) | — |
| PPM001508 | PGS000675 (snpnet.C_reactive_protein) |
PSS000655| South Asian Ancestry| 7,316 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: C-reactive protein [mg/L] | — | — | R²: 0.13562 Spearman's ρ: 0.315 |
Age, sex, PCs(1-40) | — |
| PPM001543 | PGS000675 (snpnet.C_reactive_protein) |
PSS000656| European Ancestry| 63,656 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: C-reactive protein [mg/L] | — | — | R²: 0.14786 Spearman's ρ: 0.353 |
Age, sex, PCs(1-40) | — |
| PPM001593 | PGS000675 (snpnet.C_reactive_protein) |
PSS000801| European Ancestry| 2,128 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: C-reactive protein [mg/L] | — | — | Spearman's ρ: 0.254 | Age, sex | — |
| PPM001403 | PGS000675 (snpnet.C_reactive_protein) |
PSS000652| African Ancestry| 6,006 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: C-reactive protein [mg/L] | — | — | R²: 0.07691 Spearman's ρ: 0.196 |
Age, sex, PCs(1-40) | — |
| PPM007302 | PGS000675 (snpnet.C_reactive_protein) |
PSS007138| European Ancestry| 23,721 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: C-reactive protein | — | — | R²: 0.03906 [0.03434, 0.04378] Incremental R2 (full-covars): 0.02747 PGS R2 (no covariates): 0.03496 [0.03048, 0.03945] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007303 | PGS000675 (snpnet.C_reactive_protein) |
PSS007139| South Asian Ancestry| 7,404 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: C-reactive protein | — | — | R²: 0.05308 [0.04342, 0.06274] Incremental R2 (full-covars): 0.03091 PGS R2 (no covariates): 0.04237 [0.03364, 0.0511] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007304 | PGS000675 (snpnet.C_reactive_protein) |
PSS007140| European Ancestry| 64,332 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: C-reactive protein | — | — | R²: 0.03346 [0.03079, 0.03613] Incremental R2 (full-covars): 0.02832 PGS R2 (no covariates): 0.03414 [0.03145, 0.03684] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007300 | PGS000675 (snpnet.C_reactive_protein) |
PSS007136| African Ancestry| 6,088 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: C-reactive protein | — | — | R²: 0.03482 [0.02607, 0.04358] Incremental R2 (full-covars): 0.01008 PGS R2 (no covariates): 0.01186 [0.00663, 0.01709] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007301 | PGS000675 (snpnet.C_reactive_protein) |
PSS007137| East Asian Ancestry| 1,611 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: C-reactive protein | — | — | R²: 0.03926 [0.02122, 0.05729] Incremental R2 (full-covars): 0.02473 PGS R2 (no covariates): 0.02923 [0.0135, 0.04496] |
age, sex, UKB array type, Genotype PCs | — |
| PPM010443 | PGS001946 (portability-PLR_log_CRP) |
PSS009430| European Ancestry| 18,962 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3858 [0.3736, 0.3978] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010444 | PGS001946 (portability-PLR_log_CRP) |
PSS009204| European Ancestry| 3,944 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3769 [0.3497, 0.4034] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010445 | PGS001946 (portability-PLR_log_CRP) |
PSS008758| European Ancestry| 6,308 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3495 [0.3276, 0.371] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010446 | PGS001946 (portability-PLR_log_CRP) |
PSS008532| Greater Middle Eastern Ancestry| 1,124 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3484 [0.2954, 0.3991] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010447 | PGS001946 (portability-PLR_log_CRP) |
PSS008310| South Asian Ancestry| 5,978 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3629 [0.3406, 0.3847] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010448 | PGS001946 (portability-PLR_log_CRP) |
PSS008087| East Asian Ancestry| 1,710 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3027 [0.2588, 0.3454] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010449 | PGS001946 (portability-PLR_log_CRP) |
PSS007874| African Ancestry| 2,339 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.215 [0.1758, 0.2534] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010450 | PGS001946 (portability-PLR_log_CRP) |
PSS008978| African Ancestry| 3,653 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.1982 [0.1667, 0.2292] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012159 | PGS002164 (portability-ldpred2_log_CRP) |
PSS009430| European Ancestry| 18,962 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3745 [0.3621, 0.3866] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012161 | PGS002164 (portability-ldpred2_log_CRP) |
PSS008758| European Ancestry| 6,308 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3368 [0.3147, 0.3585] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012162 | PGS002164 (portability-ldpred2_log_CRP) |
PSS008532| Greater Middle Eastern Ancestry| 1,124 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3562 [0.3036, 0.4067] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012163 | PGS002164 (portability-ldpred2_log_CRP) |
PSS008310| South Asian Ancestry| 5,978 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3591 [0.3368, 0.3811] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012164 | PGS002164 (portability-ldpred2_log_CRP) |
PSS008087| East Asian Ancestry| 1,710 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.3014 [0.2574, 0.3441] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012165 | PGS002164 (portability-ldpred2_log_CRP) |
PSS007874| African Ancestry| 2,339 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.2015 [0.1621, 0.2402] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012166 | PGS002164 (portability-ldpred2_log_CRP) |
PSS008978| African Ancestry| 3,653 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.2093 [0.178, 0.2402] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012160 | PGS002164 (portability-ldpred2_log_CRP) |
PSS009204| European Ancestry| 3,944 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive protein | — | — | Partial Correlation (partial-r): 0.364 [0.3366, 0.3909] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM015649 | PGS002860 (ExPRSweb_CRP_28887542-GCST004941_LASSOSUM_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.00477 (0.0125) | — | R²: 3e-05 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015655 | PGS002861 (ExPRSweb_CRP_28887542-GCST004941_PT_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: -0.0128 (0.0131) | — | R²: 2.83e-06 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015651 | PGS002862 (ExPRSweb_CRP_28887542-GCST004941_PLINK_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: -0.0105 (0.0132) | — | R²: 2e-05 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015653 | PGS002863 (ExPRSweb_CRP_28887542-GCST004941_PRSCS_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: -0.00958 (0.0111) | — | R²: 0.00012 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015658 | PGS002864 (ExPRSweb_CRP_30710-irnt_LASSOSUM_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.101 (0.0109) | — | R²: 0.0169 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015661 | PGS002865 (ExPRSweb_CRP_30710-irnt_PT_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.105 (0.0114) | — | R²: 0.0147 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015659 | PGS002866 (ExPRSweb_CRP_30710-irnt_PLINK_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.112 (0.0113) | — | R²: 0.0171 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015657 | PGS002867 (ExPRSweb_CRP_30710-irnt_DBSLMM_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.102 (0.0109) | — | R²: 0.0172 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015660 | PGS002868 (ExPRSweb_CRP_30710-irnt_PRSCS_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.124 (0.0109) | — | R²: 0.0239 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015663 | PGS002869 (ExPRSweb_CRP_30710-raw_LASSOSUM_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.097 (0.0109) | — | R²: 0.0146 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015666 | PGS002870 (ExPRSweb_CRP_30710-raw_PT_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0763 (0.0109) | — | R²: 0.0087 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015664 | PGS002871 (ExPRSweb_CRP_30710-raw_PLINK_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0791 (0.0109) | — | R²: 0.00935 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015662 | PGS002872 (ExPRSweb_CRP_30710-raw_DBSLMM_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0685 (0.0109) | — | R²: 0.00728 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015665 | PGS002873 (ExPRSweb_CRP_30710-raw_PRSCS_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.106 (0.0108) | — | R²: 0.0178 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015669 | PGS002874 (ExPRSweb_CRP_prot-a-670_LASSOSUM_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0485 (0.0108) | — | R²: 0.00404 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015675 | PGS002875 (ExPRSweb_CRP_prot-a-670_PT_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0525 (0.0108) | — | R²: 0.00456 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015671 | PGS002876 (ExPRSweb_CRP_prot-a-670_PLINK_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0525 (0.0108) | — | R²: 0.00456 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015667 | PGS002877 (ExPRSweb_CRP_prot-a-670_DBSLMM_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0197 (0.0125) | — | R²: 0.0005 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015673 | PGS002878 (ExPRSweb_CRP_prot-a-670_PRSCS_MGI_20211120) |
PSS009998| European Ancestry| 5,147 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0082 (0.0109) | — | R²: 0.0001 | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015650 | PGS002879 (ExPRSweb_CRP_28887542-GCST004941_LASSOSUM_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0157 (0.00985) | — | R²: 1e-05 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015656 | PGS002880 (ExPRSweb_CRP_28887542-GCST004941_PT_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0274 (0.00985) | — | R²: 4e-05 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015652 | PGS002881 (ExPRSweb_CRP_28887542-GCST004941_PLINK_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0209 (0.00987) | — | R²: 2e-05 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015648 | PGS002882 (ExPRSweb_CRP_28887542-GCST004941_DBSLMM_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: -0.0111 (0.00987) | — | R²: 6.04e-06 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015654 | PGS002883 (ExPRSweb_CRP_28887542-GCST004941_PRSCS_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.00422 (0.00988) | — | R²: 3.46e-06 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015670 | PGS002884 (ExPRSweb_CRP_prot-a-670_LASSOSUM_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.456 (0.00981) | — | R²: 0.011 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015676 | PGS002885 (ExPRSweb_CRP_prot-a-670_PT_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.458 (0.00981) | — | R²: 0.011 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015672 | PGS002886 (ExPRSweb_CRP_prot-a-670_PLINK_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.458 (0.00981) | — | R²: 0.011 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015668 | PGS002887 (ExPRSweb_CRP_prot-a-670_DBSLMM_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.00643 (0.00986) | — | R²: 1.46e-06 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015674 | PGS002888 (ExPRSweb_CRP_prot-a-670_PRSCS_UKB_20211120) |
PSS010024| European Ancestry| 194,718 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: C-reactive Protein | β: 0.0997 (0.00988) | — | R²: 0.00051 | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM017455 | PGS003527 (cont-decay-log_CRP) |
PSS010890| European Ancestry| 19,083 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.13 | sex, age, deprivation index, PC1-16 | — |
| PPM017539 | PGS003527 (cont-decay-log_CRP) |
PSS010806| European Ancestry| 3,933 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.13 | sex, age, deprivation index, PC1-16 | — |
| PPM017623 | PGS003527 (cont-decay-log_CRP) |
PSS010638| European Ancestry| 6,156 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.12 | sex, age, deprivation index, PC1-16 | — |
| PPM017707 | PGS003527 (cont-decay-log_CRP) |
PSS010554| Greater Middle Eastern Ancestry| 1,095 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.12 | sex, age, deprivation index, PC1-16 | — |
| PPM017791 | PGS003527 (cont-decay-log_CRP) |
PSS010218| European Ancestry| 2,236 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.11 | sex, age, deprivation index, PC1-16 | — |
| PPM017875 | PGS003527 (cont-decay-log_CRP) |
PSS010470| South Asian Ancestry| 5,924 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.12 | sex, age, deprivation index, PC1-16 | — |
| PPM017959 | PGS003527 (cont-decay-log_CRP) |
PSS010386| East Asian Ancestry| 1,699 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.09 | sex, age, deprivation index, PC1-16 | — |
| PPM018043 | PGS003527 (cont-decay-log_CRP) |
PSS010302| African Ancestry| 2,327 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
| PPM018127 | PGS003527 (cont-decay-log_CRP) |
PSS010722| African Ancestry| 3,625 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: C-reactive protein | — | — | partial-R2: 0.04 | sex, age, deprivation index, PC1-16 | — |
| PPM020450 | PGS004335 (X30710.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: C-reactive protein (mg/L) | — | — | PGS R2 (no covariates): 0.25299 | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS008532 | — | — | 1,124 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS009430 | — | — | 18,962 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS010806 | — | — | 3,933 individuals, 38.0 % Male samples |
Mean = 54.4 years Sd = 7.5 years |
European | Polish | UKB | — |
| PSS010554 | — | — | 1,095 individuals, 60.0 % Male samples |
Mean = 51.9 years Sd = 7.9 years |
Greater Middle Eastern (Middle Eastern, North African or Persian) | Iranian | UKB | — |
| PSS010302 | — | — | 2,327 individuals, 37.0 % Male samples |
Mean = 52.5 years Sd = 8.1 years |
African American or Afro-Caribbean | Caribbean | UKB | — |
| PSS007136 | — | — | 6,088 individuals | — | African unspecified | — | UKB | — |
| PSS007137 | — | — | 1,611 individuals | — | East Asian | — | UKB | — |
| PSS007138 | — | — | 23,721 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007139 | — | — | 7,404 individuals | — | South Asian | — | UKB | — |
| PSS007140 | — | — | 64,332 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009998 | C-REACTIVE PROTEIN SCREEN (LOINC: 1988-5); Quantitative | — | 5,147 individuals | — | European | — | MGI | — |
| PSS009204 | — | — | 3,944 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS008310 | — | — | 5,978 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS000376 | We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 1,354 individuals, 47.56 % Male samples |
Mean = 16.22 years Sd = 0.66 years |
European | — | TRAILS | — |
| PSS010722 | — | — | 3,625 individuals, 46.0 % Male samples |
Mean = 51.9 years Sd = 8.1 years |
African unspecified | Nigerian | UKB | — |
| PSS010470 | — | — | 5,924 individuals, 54.0 % Male samples |
Mean = 53.3 years Sd = 8.4 years |
South Asian | Indian | UKB | — |
| PSS010024 | Field ID: 30710; Quantitative | — | 194,718 individuals | — | European | — | UKB | — |
| PSS010218 | — | — | 2,236 individuals, 45.0 % Male samples |
Mean = 58.1 years Sd = 7.1 years |
European | Ashkenazi | UKB | — |
| PSS008978 | — | — | 3,653 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS008087 | — | — | 1,710 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
| PSS000652 | — | — | 6,006 individuals | — | African unspecified | — | UKB | — |
| PSS000653 | — | — | 1,077 individuals | — | East Asian | — | UKB | — |
| PSS000654 | — | — | 23,534 individuals | — | European | Non-British White | UKB | — |
| PSS000655 | — | — | 7,316 individuals | — | South Asian | — | UKB | — |
| PSS000656 | — | — | 63,656 individuals | — | European (British) |
— | UKB | — |
| PSS010890 | — | — | 19,083 individuals, 46.0 % Male samples |
Mean = 56.9 years Sd = 7.9 years |
European | white British | UKB | — |
| PSS010638 | — | — | 6,156 individuals, 45.0 % Male samples |
Mean = 54.5 years Sd = 8.4 years |
European | Italian | UKB | — |
| PSS008758 | — | — | 6,308 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS010386 | — | — | 1,699 individuals, 33.0 % Male samples |
Mean = 52.4 years Sd = 7.8 years |
East Asian | Chinese | UKB | — |
| PSS000801 | — | — | 2,128 individuals | — | European | Participants self-identifying as white | MESA | — |
| PSS007874 | — | — | 2,339 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |