Polygenic Score (PGS) ID: PGS003224

Predicted Trait
Reported Trait Estimated glomerular filtration rate
Mapped Trait(s) glomerular filtration rate (EFO_0005208)
Additional Trait Information eGFR; Quantitative
Released in PGS Catalog: Nov. 23, 2022
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Score Details

Score Construction
PGS Name ExPRSweb_eGFR_20171017-MW-eGFR-EA_LASSOSUM_UKB_20211120
Development Method
Name lassosum
Parameters Lassosum 0.4.4 (MAF >= 1%; autosomal variants only)s=0.9;Lambda=0.00207
Variants
Original Genome Build GRCh37
Number of Variants 456,946
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000393
Citation (link to publication) Ma Y et al. Am J Hum Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
783,978 individuals (100%)
Score Development/Training
European: 100%
195,035 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008059
Europe PMC: 31152163
 783,978 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 195,035 individuals European UKB estimated glomerular filtration rate (eGFR) on the natural scale by using the harmonized serum creatinine values (data field 30700), race and sex information, and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation; Quantitative — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016110 PSS010037|
European Ancestry|
195,023 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: eGFR β: 3.46 (0.0254) — R²: 0.0688 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010037 estimated glomerular filtration rate (eGFR) on the natural scale by using the harmonized serum creatinine values (data field 30700), race and sex information, and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation; Quantitative — 195,023 individuals — European — UKB —