Polygenic Score (PGS) ID: PGS003362

Predicted Trait
Reported Trait Age of smoking initiation
Mapped Trait(s) age at initiation of smoking (EFO_0021784)
Released in PGS Catalog: Dec. 20, 2022
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Score Details

Score Construction
PGS Name GSCAN_AgeSmk_2022_PRS_WEIGHTS_AMR
Development Method
Name LDpred
Parameters NR
Variants
Original Genome Build NR
Number of Variants 1,073,689
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000410
Citation (link to publication) Saunders GRB et al. Nature (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Hispanic or Latin American: 100%
844 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 844 individuals Hispanic or Latin American MESA, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016218 PSS010061|
Hispanic or Latin American Ancestry|
1,132 individuals
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Reported Trait: Age of smoking initiation β: 0.058 (0.047) — ∆ R^2: 0.003 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010061 — — 1,132 individuals — Hispanic or Latin American — Add Health —