Trait: age at initiation of smoking

Experimental Factor Ontology (EFO) Information
Identifier EFO_0021784
Description Age of initation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003361
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_AFR)
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Age of smoking initiation age at initiation of smoking 1,193,754
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003361/ScoringFiles/PGS003361.txt.gz
PGS003362
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_AMR)
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Age of smoking initiation age at initiation of smoking 1,073,689
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003362/ScoringFiles/PGS003362.txt.gz
PGS003363
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_EAS)
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Age of smoking initiation age at initiation of smoking 858,406
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003363/ScoringFiles/PGS003363.txt.gz
PGS003364
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_EUR)
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Age of smoking initiation age at initiation of smoking 1,055,960
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003364/ScoringFiles/PGS003364.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016217 PGS003361
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_AFR)
 PSS010064|
African Ancestry|
2,199 individuals
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Reported Trait: Age of smoking initiation β: 0.045 (0.06) — ∆ R^2: 0.001 — —
PPM016218 PGS003362
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_AMR)
 PSS010061|
Hispanic or Latin American Ancestry|
1,132 individuals
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Reported Trait: Age of smoking initiation β: 0.058 (0.047) — ∆ R^2: 0.003 — —
PPM016219 PGS003363
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_EAS)
 PSS010062|
East Asian Ancestry|
525 individuals
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Reported Trait: Age of smoking initiation β: 0.057 (0.088) — ∆ R^2: 0.003 — —
PPM016220 PGS003364
(GSCAN_AgeSmk_2022_PRS_WEIGHTS_EUR)
 PSS010063|
European Ancestry|
6,092 individuals
 PGP000410 |
Saunders GRB et al. Nature (2022)
 Reported Trait: Age of smoking initiation β: 0.12 (0.018) — ∆ R^2: 0.014 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010064 — — 2,199 individuals — African unspecified — Add Health —
PSS010061 — — 1,132 individuals — Hispanic or Latin American — Add Health —
PSS010062 — — 525 individuals — East Asian — Add Health —
PSS010063 — — 6,092 individuals — European — Add Health —